Control of gene therapy by MDR1 and EGR1 promoter sequences in transcriptional targeting by chemotherapy (Review)

  • Authors:
    • Carlos A. Lopez
    • James O. Park
    • Helena J. Mauceri
    • Michael A. Beckett
    • Ralph R. Weichselbaum
    • Mitchell C. Posner
  • View Affiliations

  • Published online on: March 1, 2004     https://doi.org/10.3892/ijo.24.3.731
  • Pages: 731-736
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Abstract

The promising benefits of cancer gene therapy have been limited by the inability to deliver therapeutic genes homogeneously throughout the tumor mass and to control gene expression within the tumor cells. Transcriptional targeting, the use of DNA regulatory promoter sequences to localize transgene expression, has been employed as a solution to circumvent these limitations. TNF-α is a cytokine that exhibits potent anticancer properties, but its utility following systemic administration is limited by toxicity. We review a strategy whereby ligating TNF-α to segments of the chemo-inducible EGR1 or MDR1 promoters activates expression of TNF-α cDNA and enhances effectiveness of gene therapy and chemotherapy.

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March 2004
Volume 24 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
APA
Lopez, C.A., Park, J.O., Mauceri, H.J., Beckett, M.A., Weichselbaum, R.R., & Posner, M.C. (2004). Control of gene therapy by MDR1 and EGR1 promoter sequences in transcriptional targeting by chemotherapy (Review). International Journal of Oncology, 24, 731-736. https://doi.org/10.3892/ijo.24.3.731
MLA
Lopez, C. A., Park, J. O., Mauceri, H. J., Beckett, M. A., Weichselbaum, R. R., Posner, M. C."Control of gene therapy by MDR1 and EGR1 promoter sequences in transcriptional targeting by chemotherapy (Review)". International Journal of Oncology 24.3 (2004): 731-736.
Chicago
Lopez, C. A., Park, J. O., Mauceri, H. J., Beckett, M. A., Weichselbaum, R. R., Posner, M. C."Control of gene therapy by MDR1 and EGR1 promoter sequences in transcriptional targeting by chemotherapy (Review)". International Journal of Oncology 24, no. 3 (2004): 731-736. https://doi.org/10.3892/ijo.24.3.731