Evaluation of HER-2/neu status by real-time quantitative PCR in malignant cartilaginous tumors

  • Authors:
    • Hye-Rim Park
    • Youn-Wha Kim
    • Woon Won Jung
    • Hyun Sook Kim
    • K. K. Unni
    • Yong-Koo Park
  • View Affiliations

  • Published online on: March 1, 2004     https://doi.org/10.3892/ijo.24.3.575
  • Pages: 575-580
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Abstract

The expression of HER-2/neu has been proposed to be a prognostic indicator in osteosarcoma. To clarify the actual frequency of HER-2/neu expression in primary malignant cartilaginous tumors, we examined 89 cases comprising 17 conventional chondrosarcomas, 33 mesenchymal chondrosarcomas, and 39 clear cell chondrosarcomas. We used real-time PCR (LightCycler) assay to quantify the HER-2/neu gene status. The crossing point of HER-2 in normal control bone was 27.77. The crossing points of HER-2 in conventional, mesenchymal, and clear cell chondrosarcomas were 28.48±1.79, 27.74±3.02, 28.57±1.54, respectively. In conclusion, the amplification and overexpression of the HER-2/neu oncogene is absent or at least very rare in malignant cartilaginous tumors. The level of expression of HER-2/neu was similar in all cartilaginous tumor types.

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March 2004
Volume 24 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Park, H., Kim, Y., Jung, W.W., Kim, H.S., Unni, K.K., & Park, Y. (2004). Evaluation of HER-2/neu status by real-time quantitative PCR in malignant cartilaginous tumors. International Journal of Oncology, 24, 575-580. https://doi.org/10.3892/ijo.24.3.575
MLA
Park, H., Kim, Y., Jung, W. W., Kim, H. S., Unni, K. K., Park, Y."Evaluation of HER-2/neu status by real-time quantitative PCR in malignant cartilaginous tumors". International Journal of Oncology 24.3 (2004): 575-580.
Chicago
Park, H., Kim, Y., Jung, W. W., Kim, H. S., Unni, K. K., Park, Y."Evaluation of HER-2/neu status by real-time quantitative PCR in malignant cartilaginous tumors". International Journal of Oncology 24, no. 3 (2004): 575-580. https://doi.org/10.3892/ijo.24.3.575