Molecular signature in three types of hepatocellular carcinoma with different viral origin by oligonucleotide microarray

  • Authors:
    • Norio Iizuka
    • Masaaki Oka
    • Hisafumi Yamada-Okabe
    • Kenji Hamada
    • Hironobu Nakayama
    • Naohide Mori
    • Takao Tamesa
    • Toshimasa Okada
    • Norikazu Takemoto
    • Katsuhiro Matoba
    • Motonari Takashima
    • Katsuhiko Sakamoto
    • Akira Tangoku
    • Takanobu Miyamoto
    • Shunji Uchimura
    • Yoshihiko Hamamoto
  • View Affiliations

  • Published online on: March 1, 2004     https://doi.org/10.3892/ijo.24.3.565
  • Pages: 565-574
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Abstract

Chronic infection with hepatitis B or C virus (HBV or HCV) is the most clearly established risk factor for hepato-cellular carcinoma (HCC). One type of HCC (non-B, non-C HCC) also appears to develop in patients negative for both HBV and HCV. Using a supervised learning method, we investigated gene expression in 11 non-B, non-C HCCs with high-density oligonucleotide microarrays, and compared the patterns of gene expression with those of HBV-infected HCCs (B-type HCCs) and HCV-infected HCCs (C-type HCCs) in the previous dataset. Our gene selection identified 112 and 64 genes that were differentially expressed in non-B, non-C HCC in comparison with B- and C-type HCCs, respectively. In both gene selections, we found that the false discovery rate, the percentage of genes identified by chance, was less than 5%. Additionally, in combination with the previous data, our present data revealed a set of genes specific to each type of B- and C-type HCCs and non-B, non-C HCC. Among these, an interferon-induced gene, IFI27, was differentially expressed among all three types of HCCs, and this result was confirmed by RT-PCR. Thus, our present study provides a framework to characterize the molecular features in the three subtypes of HCC with different viral origin.

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March 2004
Volume 24 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Iizuka, N., Oka, M., Yamada-Okabe, H., Hamada, K., Nakayama, H., Mori, N. ... Hamamoto, Y. (2004). Molecular signature in three types of hepatocellular carcinoma with different viral origin by oligonucleotide microarray. International Journal of Oncology, 24, 565-574. https://doi.org/10.3892/ijo.24.3.565
MLA
Iizuka, N., Oka, M., Yamada-Okabe, H., Hamada, K., Nakayama, H., Mori, N., Tamesa, T., Okada, T., Takemoto, N., Matoba, K., Takashima, M., Sakamoto, K., Tangoku, A., Miyamoto, T., Uchimura, S., Hamamoto, Y."Molecular signature in three types of hepatocellular carcinoma with different viral origin by oligonucleotide microarray". International Journal of Oncology 24.3 (2004): 565-574.
Chicago
Iizuka, N., Oka, M., Yamada-Okabe, H., Hamada, K., Nakayama, H., Mori, N., Tamesa, T., Okada, T., Takemoto, N., Matoba, K., Takashima, M., Sakamoto, K., Tangoku, A., Miyamoto, T., Uchimura, S., Hamamoto, Y."Molecular signature in three types of hepatocellular carcinoma with different viral origin by oligonucleotide microarray". International Journal of Oncology 24, no. 3 (2004): 565-574. https://doi.org/10.3892/ijo.24.3.565