Expression of the anti-apoptotic gene survivin in myelodysplastic syndrome

  • Authors:
    • Adel Badran
    • Akira Yoshida
    • Yuji Wano
    • Masato Mutoh
    • Shin Imamura
    • Taro Yamashita
    • Hiroshi Tsutani
    • Manabu Inuzuka
    • Takanori Ueda
  • View Affiliations

  • Published online on: January 1, 2003     https://doi.org/10.3892/ijo.22.1.59
  • Pages: 59-64
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Abstract

Survivin is a member of the inhibitor of apoptosis protein (IAPs) family and considered to play a pivotal role in oncogenesis. We present the first report of survivin expression profile in myelodysplastic syndrome (MDS). Expression of survivin messenger RNA was evaluated by semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) in patients with MDS and acute myeloid leukemia (AML). Eleven out of 12 patients with refractory anemia (RA) (91.6%), and all 3 patients with refractory anemia with excess blasts in transformation (RAEBt) (100%), were positive for survivin expression with the majority of cases showing abundant levels of the survivin transcript. On the other hand, expression of survivin was undetectable in the 4 patients with chronic myelomonocytic leukemia (CMMoL). The level and frequency of survivin expression in patients with refractory anemia were compared to those in patients with AML. Out of 12 patients with de novo AML, 5 patients (41.7%) showed detectable levels of survivin expression. Abundant survivin expression in RA was also confirmed by immunohistochemistry. In contrast, survivin was almost absent in two cases with aplastic anemia. We propose that high levels of survivin expression can serve as a reliable diagnostic marker of RA in MDS.

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January 2003
Volume 22 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Badran, A., Yoshida, A., Wano, Y., Mutoh, M., Imamura, S., Yamashita, T. ... Ueda, T. (2003). Expression of the anti-apoptotic gene survivin in myelodysplastic syndrome. International Journal of Oncology, 22, 59-64. https://doi.org/10.3892/ijo.22.1.59
MLA
Badran, A., Yoshida, A., Wano, Y., Mutoh, M., Imamura, S., Yamashita, T., Tsutani, H., Inuzuka, M., Ueda, T."Expression of the anti-apoptotic gene survivin in myelodysplastic syndrome". International Journal of Oncology 22.1 (2003): 59-64.
Chicago
Badran, A., Yoshida, A., Wano, Y., Mutoh, M., Imamura, S., Yamashita, T., Tsutani, H., Inuzuka, M., Ueda, T."Expression of the anti-apoptotic gene survivin in myelodysplastic syndrome". International Journal of Oncology 22, no. 1 (2003): 59-64. https://doi.org/10.3892/ijo.22.1.59