Combined deficiency of hMLH1, hMSH2, hMSH3 and hMSH6 is an independent prognostic factor in colorectal cancer

  • Authors:
    • Agneta Jansson
    • Gunnar Arbman
    • Hong Zhang
    • Xiao-Feng Sun
  • View Affiliations

  • Published online on: January 1, 2003     https://doi.org/10.3892/ijo.22.1.41
  • Pages: 41-49
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Abstract

We examined biological and clinicopathological significance of individual and combined hMLH1, hMSH2, hMSH3 and hMSH6 expression with immunohistochemistry in 301 unselected colorectal cancers. Weak hMLH1 expression was correlated to microsatellite instability (P=0.04), negative p53 expression (P=0.005) and mucinous carcinomas (P=0.02). Weak hMSH2 expression was related to negative ras (P<0.001) and p53 expression (P=0.005), and better survival (P=0.03). hMSH2, hMSH3 and hMSH6, as well as hMLH1, hMSH2, hMSH3 and hMSH6, were combined into a ‘functional’ and a ‘less-functional’ group, respectively. Both ‘less-functional’ groups were/tended to be associated with microsatellite instability, negative ras and p53 expression, and better survival. In summary, hMLH1 and hMSH2 were more important when investigated individually, and the combined groups were more related to the mutator pathway, suggesting that combined deficiencies of the proteins are more efficiently involved in the mutator pathway. Our result from weak versus strong staining may suggest that the intensity of staining should be considered in future studies on mismatch repair proteins.

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January 2003
Volume 22 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Jansson, A., Arbman, G., Zhang, H., & Sun, X. (2003). Combined deficiency of hMLH1, hMSH2, hMSH3 and hMSH6 is an independent prognostic factor in colorectal cancer. International Journal of Oncology, 22, 41-49. https://doi.org/10.3892/ijo.22.1.41
MLA
Jansson, A., Arbman, G., Zhang, H., Sun, X."Combined deficiency of hMLH1, hMSH2, hMSH3 and hMSH6 is an independent prognostic factor in colorectal cancer". International Journal of Oncology 22.1 (2003): 41-49.
Chicago
Jansson, A., Arbman, G., Zhang, H., Sun, X."Combined deficiency of hMLH1, hMSH2, hMSH3 and hMSH6 is an independent prognostic factor in colorectal cancer". International Journal of Oncology 22, no. 1 (2003): 41-49. https://doi.org/10.3892/ijo.22.1.41