Profiling of gene expression associated with hepatolithiasis by complementary DNA expression array
- Authors:
- Toshio Kokuryo
- Tatsuyoshi Yamamoto
- Koji Oda
- Junichi Kamiya
- Yuji Nimura
- Takeshi Senga
- Yoshinari Yasuda
- Yoshiyuki Ohno
- Yasuni Nakanuma
- Miin-Fu Chen
- Yi-Yin Jan
- Ta-Sen Yeh
- Cheng-Taug Chiu
- Ling-Ling Hsieh
- Michinari Hamaguchi
- Published online on: January 1, 2003 https://doi.org/10.3892/ijo.22.1.175
- Pages: 175-179
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Abstract
By use of cDNA expression array method, we compared the expression profiles of genes in hepatolithiasis tissues with those of paired normal tissues. Expression of 1176 cancer related genes that include 33 tumor suppressor genes, 100 proto-oncogenes and 37 DNA damage repair genes were examined in this study. We found that expression of tumor suppressor genes and proto-oncogenes was systemically activated in hepatholithiasis tissues, suggesting that expression of genes controlling cell growth becomes unstable in liver lobe of hepatolithiasis. In contrast, expression of DNA damage repair genes were not activated but rather remained unchanged in hepatholithiasis tissues, suggesting that repair process is not strongly activated but rather impaired in hepatholithiasis tissues.
