Expression of angiogenic factors including VEGFs and the effects of hypoxia and thalidomide on human myeloma cells

  • Authors:
    • Kenichiro Yata
    • Takemi Otsuki
    • Junichi Kurebayashi
    • Masako Uno
    • Tomohiro Fujii
    • Yoshihito Yawata
    • Akiko Takata
    • Fuminori Hyodoh
    • Takashi Sugihara
  • View Affiliations

  • Published online on: January 1, 2003     https://doi.org/10.3892/ijo.22.1.165
  • Pages: 165-173
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Abstract

Angiogenic factors are major causes of tumor progression in hematological malignancies, particularly multiple myeloma, as well as solid tumors. The introduction of thalidomide as an anti-angiogenic agent in myeloma treatment has demonstrated the importance of angiogenic factors in the progression of myeloma. However, the direct effects of angiogenic factors, particularly VEGFs, hypoxia, and thalidomide, on myeloma cells are not been documented. In this study, we demonstrate increased expression and production levels of VEGF in myeloma compared to non-myelomatous hematological lines, resistance to hypoxia and enhancement of VEGF-A production by hypoxia in myeloma, and direct growth inhibition of myeloma cells due to apoptosis and G1 arrest caused by TNFα upregulation induced by thalidomide. These findings may encourage the clinical use of anti-angiogenic agents for their cytostatic effects and the prevention of progression.

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January 2003
Volume 22 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Yata, K., Otsuki, T., Kurebayashi, J., Uno, M., Fujii, T., Yawata, Y. ... Sugihara, T. (2003). Expression of angiogenic factors including VEGFs and the effects of hypoxia and thalidomide on human myeloma cells. International Journal of Oncology, 22, 165-173. https://doi.org/10.3892/ijo.22.1.165
MLA
Yata, K., Otsuki, T., Kurebayashi, J., Uno, M., Fujii, T., Yawata, Y., Takata, A., Hyodoh, F., Sugihara, T."Expression of angiogenic factors including VEGFs and the effects of hypoxia and thalidomide on human myeloma cells". International Journal of Oncology 22.1 (2003): 165-173.
Chicago
Yata, K., Otsuki, T., Kurebayashi, J., Uno, M., Fujii, T., Yawata, Y., Takata, A., Hyodoh, F., Sugihara, T."Expression of angiogenic factors including VEGFs and the effects of hypoxia and thalidomide on human myeloma cells". International Journal of Oncology 22, no. 1 (2003): 165-173. https://doi.org/10.3892/ijo.22.1.165