The IL-6 receptor super-antagonist Sant7 enhances antiproliferative and apoptotic effects induced by dexamethasone and zoledronic acid on multiple myeloma cells

  • Authors:
    • Pierfrancesco Tassone
    • Eulalia Galea
    • Samantha Forciniti
    • Pierosandro Tagliaferri
    • Salvatore Venuta
  • View Affiliations

  • Published online on: October 1, 2002     https://doi.org/10.3892/ijo.21.4.867
  • Pages: 867-873
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Abstract

Interleukin-6 (IL-6) is the major growth and survival factor for multiple myeloma (MM), and has been shown to protect MM cells from apoptosis induced by a variety of agents. IL-6 receptor antagonists, which prevent the assembly of functional IL-6 receptor complexes, inhibit cell proliferation and induce apoptosis in MM cells. We have investigated whether the IL-6 receptor super-antagonist Sant7 might enhance the antiproliferative and apoptotic effects induced by the combination of dexamethasone (Dex) and zoledronic acid (Zln) on human MM cell lines and primary cells from MM patients. Here we show that each of these compounds individually induced detectable antiproliferative effects on MM cells. Sant7 significantly enhanced growth inhibition and apoptosis induced by Dex and Zln on both MM cell lines and primary MM cells. These results indicate that overcoming IL-6 mediated cell resistance by Sant7 potentiates the effect of glucocorticoides and bisphosphonates on MM cell growth and survival, providing a rationale for therapies including IL-6 antagonists in MM.

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October 2002
Volume 21 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Tassone, P., Galea, E., Forciniti, S., Tagliaferri, P., & Venuta, S. (2002). The IL-6 receptor super-antagonist Sant7 enhances antiproliferative and apoptotic effects induced by dexamethasone and zoledronic acid on multiple myeloma cells. International Journal of Oncology, 21, 867-873. https://doi.org/10.3892/ijo.21.4.867
MLA
Tassone, P., Galea, E., Forciniti, S., Tagliaferri, P., Venuta, S."The IL-6 receptor super-antagonist Sant7 enhances antiproliferative and apoptotic effects induced by dexamethasone and zoledronic acid on multiple myeloma cells". International Journal of Oncology 21.4 (2002): 867-873.
Chicago
Tassone, P., Galea, E., Forciniti, S., Tagliaferri, P., Venuta, S."The IL-6 receptor super-antagonist Sant7 enhances antiproliferative and apoptotic effects induced by dexamethasone and zoledronic acid on multiple myeloma cells". International Journal of Oncology 21, no. 4 (2002): 867-873. https://doi.org/10.3892/ijo.21.4.867