Combined use of percutaneous ethanol injection and radiofrequency ablation for the effective treatment of hepatocelluar carcinoma

  • Authors:
    • K. Kurokohchi
    • S. Watanabe
    • T. Masaki
    • N. Hosomi
    • T. Funaki
    • K. Arima
    • S. Yoshida
    • Y. Miyauchi
    • S. Kuriyama
  • View Affiliations

  • Published online on: October 1, 2002     https://doi.org/10.3892/ijo.21.4.841
  • Pages: 841-846
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Abstract

Radiofrequency ablation (RFA) and percutaneous ethanol injection (PEI) therapy are currently used for the treatment of hepatocellular carcinoma (HCC). The purpose of this study was to evaluate the usefulness of combination therapy of PEI and RFA (PEI-RFA). Seventy-three patients with biopsy-proven HCC and liver cirrhosis underwent RFA after a bolus injection of ethanol into HCC. The volume of coagulated necrosis in the liver caused by PEI-RFA was estimated and compared with that by RFA alone. Coagulated necrosis areas in the liver of patients treated with PEI-RFA were significantly larger than those of patients treated with RFA alone. In PEI-RFA group, the volume of coagulated necrosis was significantly correlated with the amounts of ethanol injected into HCC. No major complications were observed during and after the PEI-RFA treatment. These results indicate that PEI-RFA is more effective than RFA alone and can make dramatic improvement of therapeutic effects in RFA therapy for HCC with fewer sessions of treatments. Therefore, PEI-RFA is considered to be a practical and promising option and may open up new avenues for the treatment of HCC.

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October 2002
Volume 21 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Kurokohchi, K., Watanabe, S., Masaki, T., Hosomi, N., Funaki, T., Arima, K. ... Kuriyama, S. (2002). Combined use of percutaneous ethanol injection and radiofrequency ablation for the effective treatment of hepatocelluar carcinoma. International Journal of Oncology, 21, 841-846. https://doi.org/10.3892/ijo.21.4.841
MLA
Kurokohchi, K., Watanabe, S., Masaki, T., Hosomi, N., Funaki, T., Arima, K., Yoshida, S., Miyauchi, Y., Kuriyama, S."Combined use of percutaneous ethanol injection and radiofrequency ablation for the effective treatment of hepatocelluar carcinoma". International Journal of Oncology 21.4 (2002): 841-846.
Chicago
Kurokohchi, K., Watanabe, S., Masaki, T., Hosomi, N., Funaki, T., Arima, K., Yoshida, S., Miyauchi, Y., Kuriyama, S."Combined use of percutaneous ethanol injection and radiofrequency ablation for the effective treatment of hepatocelluar carcinoma". International Journal of Oncology 21, no. 4 (2002): 841-846. https://doi.org/10.3892/ijo.21.4.841