Open Access

Role of microRNAs in remodeling the tumor microenvironment (Review)

  • Authors:
    • Zhaoji Pan
    • Yiqing Tian
    • Guoping Niu
    • Chengsong Cao
  • View Affiliations

  • Published online on: December 24, 2019     https://doi.org/10.3892/ijo.2019.4952
  • Pages: 407-416
  • Copyright: © Pan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

MicroRNAs (miRNAs) are short non‑coding RNAs that are known to regulate gene expression at the post‑transcriptional level. miRNA expression is often deregulated in several human cancers, affecting the communication between tumor stroma and tumor cells, among other functions. Understanding the role of miRNAs in the tumor microenvironment is crucial for fully elucidating the molecular mechanisms underlying tumor progression and exploring novel diagnostic biomarkers and therapeutic targets. The present review focused on the role of miRNAs in remodeling the tumor microenvironment, with an emphasis on their impact on tumor growth, metastasis and resistance to treatment, as well as their potential clinical applications.
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February 2020
Volume 56 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Pan, Z., Tian, Y., Niu, G., & Cao, C. (2020). Role of microRNAs in remodeling the tumor microenvironment (Review). International Journal of Oncology, 56, 407-416. https://doi.org/10.3892/ijo.2019.4952
MLA
Pan, Z., Tian, Y., Niu, G., Cao, C."Role of microRNAs in remodeling the tumor microenvironment (Review)". International Journal of Oncology 56.2 (2020): 407-416.
Chicago
Pan, Z., Tian, Y., Niu, G., Cao, C."Role of microRNAs in remodeling the tumor microenvironment (Review)". International Journal of Oncology 56, no. 2 (2020): 407-416. https://doi.org/10.3892/ijo.2019.4952