Open Access

SIP1 serves a role in HBx‑induced liver cancer growth and metastasis

  • Authors:
    • Yuanyuan Ye
    • Jun Yang
    • Qin Hu
    • Jinju Mao
    • Qianfan Yang
    • Hong Chen
    • Dandan Li
    • Pu Li
    • Liang Duan
    • Bo Wang
    • Juan Chen
    • Weixian Chen
  • View Affiliations

  • Published online on: September 26, 2019     https://doi.org/10.3892/ijo.2019.4884
  • Pages: 1019-1032
  • Copyright: © Ye et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Hepatitis B virus (HBV) has been revealed to be involved in the development of hepatocellular carcinoma. However, the mechanism remains to be fully elucidated. Smad‑interacting protein 1 (SIP1) is a transcriptional repressor, which serves a pivotal role in cell metastasis. In the present study, the role of SIP1 in HBx‑induced hepatocyte EMT and cancer aggressiveness was examined. It was found that HBV X protein (HBx) increased the expression of SIP1 and recruited it to the promoter of E‑cadherin, resulting in depression of the transcription of E‑cadherin. Histone deacetylase 1 was also found to be involved in the repressive complex formation. Furthermore, in an orthotopic tumor transplantation model in vivo, HBx promoted tumor growth and metastasis, whereas the knockdown of SIP1 attenuated the effect of HBx. These results indicate a novel mechanism for the development of HBV‑related liver cancer.
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November 2019
Volume 55 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Ye, Y., Yang, J., Hu, Q., Mao, J., Yang, Q., Chen, H. ... Chen, W. (2019). SIP1 serves a role in HBx‑induced liver cancer growth and metastasis. International Journal of Oncology, 55, 1019-1032. https://doi.org/10.3892/ijo.2019.4884
MLA
Ye, Y., Yang, J., Hu, Q., Mao, J., Yang, Q., Chen, H., Li, D., Li, P., Duan, L., Wang, B., Chen, J., Chen, W."SIP1 serves a role in HBx‑induced liver cancer growth and metastasis". International Journal of Oncology 55.5 (2019): 1019-1032.
Chicago
Ye, Y., Yang, J., Hu, Q., Mao, J., Yang, Q., Chen, H., Li, D., Li, P., Duan, L., Wang, B., Chen, J., Chen, W."SIP1 serves a role in HBx‑induced liver cancer growth and metastasis". International Journal of Oncology 55, no. 5 (2019): 1019-1032. https://doi.org/10.3892/ijo.2019.4884