Knockdown of SNHG15 suppresses renal cell carcinoma proliferation and EMT by regulating the NF-κB signaling pathway

  • Authors:
    • Yang Du
    • Chuize Kong
    • Yuyan Zhu
    • Meng Yu
    • Zeliang Li
    • Jianbin Bi
    • Zhenhua Li
    • Xiankui Liu
    • Zhe Zhang
    • Xiuyue Yu
  • View Affiliations

  • Published online on: May 4, 2018     https://doi.org/10.3892/ijo.2018.4395
  • Pages: 384-394
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Abstract

Aberrant expression of long noncoding RNAs (lncRNAs) is associated with cancer tumorigenesis and progression. It has been suggested that lncRNAs may be potential clinical diagnostic and prognostic biomarkers, and therapeutic targets. In the present study, the expression levels of small nucleolar RNA host gene 15 (SNHG15) were significantly upregulated in renal cell carcinoma (RCC) tissues and cell lines compared with in adjacent tissues and a proximal tubule epithelial cell line, as determined by reverse transcription‑quantitative polymerase chain reaction. Subsequently, knockdown of SNHG15 expression with small interfering RNA inhibited RCC proliferation, invasion and migration, was determined by western blotting and Transwell assays. Furthermore, the present study suggested that SNHG15 may be involved in the nuclear factor‑κB signaling pathway, induce the epithelial‑mesenchymal transition process, and promote RCC invasion and migration.
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July 2018
Volume 53 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
APA
Du, Y., Kong, C., Zhu, Y., Yu, M., Li, Z., Bi, J. ... Yu, X. (2018). Knockdown of SNHG15 suppresses renal cell carcinoma proliferation and EMT by regulating the NF-κB signaling pathway. International Journal of Oncology, 53, 384-394. https://doi.org/10.3892/ijo.2018.4395
MLA
Du, Y., Kong, C., Zhu, Y., Yu, M., Li, Z., Bi, J., Li, Z., Liu, X., Zhang, Z., Yu, X."Knockdown of SNHG15 suppresses renal cell carcinoma proliferation and EMT by regulating the NF-κB signaling pathway". International Journal of Oncology 53.1 (2018): 384-394.
Chicago
Du, Y., Kong, C., Zhu, Y., Yu, M., Li, Z., Bi, J., Li, Z., Liu, X., Zhang, Z., Yu, X."Knockdown of SNHG15 suppresses renal cell carcinoma proliferation and EMT by regulating the NF-κB signaling pathway". International Journal of Oncology 53, no. 1 (2018): 384-394. https://doi.org/10.3892/ijo.2018.4395