Open Access

Overexpression of PLIN2 is a prognostic marker and attenuates tumor progression in clear cell renal cell carcinoma

  • Authors:
    • Qi Cao
    • Hailong Ruan
    • Keshan Wang
    • Zhengshuai Song
    • Lin Bao
    • Tianbo Xu
    • Haibing Xiao
    • Cheng Wang
    • Gong Cheng
    • Junwei Tong
    • Xiangui Meng
    • Di Liu
    • Hongmei Yang
    • Ke Chen
    • Xiaoping Zhang
  • View Affiliations

  • Published online on: April 26, 2018     https://doi.org/10.3892/ijo.2018.4384
  • Pages: 137-147
  • Copyright: © Cao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Clear cell renal cell carcinoma (ccRCC) is the most common renal malignancy in adults, the incidence of which continues to increase. The lipid droplet protein perilipin 2 (PLIN2), which was originally considered an RNA transcript, is markedly expressed during adipocyte differentiation. In addition, it has been observed to be elevated in numerous types of cancer, including ccRCC; however, its essential function remains unclear in ccRCC. The present study examined the expression of PLIN2 in ccRCC, and aimed to determine the association between PLIN2 expression and patient survival. The present study mined the transcriptional, clinicopathological and survival data of PLIN2 in patients with ccRCC through The Cancer Genome Atlas. The expression levels of PLIN2 were also detected in human ccRCC tissues and cell lines by western blotting and immunohistochemistry, and its biological role was identified by functional analysis. The results demonstrated that PLIN2 was predominantly elevated in RCC tissues and cells. In addition, the expression levels of PLIN2 were significantly associated with various clinicopathological factors, and high PLIN2 expression was associated with a good prognosis. The results of a multivariate analysis demonstrated that high PLIN2 expression was an independent prognostic indicator of overall survival (hazard ratio, 0.586; P=0.001). Furthermore, PLIN2 knockdown promoted proliferation of ccRCC cells, and enhanced cell invasion and migration. These results suggested that PLIN2 may be considered a novel prognostic factor in ccRCC and a specific diagnostic indicator for patients with ccRCC. Furthermore, it could be a potential novel target for the clinical treatment of ccRCC.
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July 2018
Volume 53 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Cao, Q., Ruan, H., Wang, K., Song, Z., Bao, L., Xu, T. ... Zhang, X. (2018). Overexpression of PLIN2 is a prognostic marker and attenuates tumor progression in clear cell renal cell carcinoma. International Journal of Oncology, 53, 137-147. https://doi.org/10.3892/ijo.2018.4384
MLA
Cao, Q., Ruan, H., Wang, K., Song, Z., Bao, L., Xu, T., Xiao, H., Wang, C., Cheng, G., Tong, J., Meng, X., Liu, D., Yang, H., Chen, K., Zhang, X."Overexpression of PLIN2 is a prognostic marker and attenuates tumor progression in clear cell renal cell carcinoma". International Journal of Oncology 53.1 (2018): 137-147.
Chicago
Cao, Q., Ruan, H., Wang, K., Song, Z., Bao, L., Xu, T., Xiao, H., Wang, C., Cheng, G., Tong, J., Meng, X., Liu, D., Yang, H., Chen, K., Zhang, X."Overexpression of PLIN2 is a prognostic marker and attenuates tumor progression in clear cell renal cell carcinoma". International Journal of Oncology 53, no. 1 (2018): 137-147. https://doi.org/10.3892/ijo.2018.4384