Open Access

Differences between carcinoma of the cecum and ascending colon: Evidence based on clinical and embryological data

  • Authors:
    • Xin Xie
    • Zhangjian Zhou
    • Yongchun Song
    • Wei Wang
    • Chengxue Dang
    • Hao Zhang
  • View Affiliations

  • Published online on: April 12, 2018     https://doi.org/10.3892/ijo.2018.4366
  • Pages: 87-98
  • Copyright: © Xie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Developing rapidly from the cecal diverticulum in a 5-week-old embryo, the cecum, which is developed from the caudal limb of the midgut loop, is different from the ascending colon. The aim of this study was to analyze the different clinicopathological and biological characteristics of patients with carcinoma of the cecum and ascending colon. We accessed data for 59,035 patients with adenocarcinomas of the cecum and ascending colon from the Surveillance, Epidemiology and End Results database to explore the potential associations between the clinicopathological characteristics and overall survival. Furthermore, we analyzed the differences in gene expression between the two segments in the Gene Expression Omnibus database. The results were validated in The Cancer Genome Atlas database, as well as with another independent dataset from the First Affiliated Hospital of Xi'an Jiaotong University. The results of this study revealed the potential prognostic differences between adenocarcinoma of the cecum and ascending colon, which may be caused by the differential expression levels of the SLCO1B3 gene. When including the expression levels of SLCO1B3 in intraoperatively examined lymph nodes, 8 factors were found able to predict the prognosis of patients with carcinomas of the cecum and ascending colon. As regards the surgical therapeutic strategies, the resection of >15 local lymph nodes is appropriate for improving the prognosis of patients.
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July 2018
Volume 53 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Xie, X., Zhou, Z., Song, Y., Wang, W., Dang, C., & Zhang, H. (2018). Differences between carcinoma of the cecum and ascending colon: Evidence based on clinical and embryological data. International Journal of Oncology, 53, 87-98. https://doi.org/10.3892/ijo.2018.4366
MLA
Xie, X., Zhou, Z., Song, Y., Wang, W., Dang, C., Zhang, H."Differences between carcinoma of the cecum and ascending colon: Evidence based on clinical and embryological data". International Journal of Oncology 53.1 (2018): 87-98.
Chicago
Xie, X., Zhou, Z., Song, Y., Wang, W., Dang, C., Zhang, H."Differences between carcinoma of the cecum and ascending colon: Evidence based on clinical and embryological data". International Journal of Oncology 53, no. 1 (2018): 87-98. https://doi.org/10.3892/ijo.2018.4366