Neutrophils in cancer development and progression: Roles, mechanisms, and implications (Review)

  • Authors:
    • Xu Zhang
    • Wen Zhang
    • Xiao Yuan
    • Min Fu
    • Hui Qian
    • Wenrong Xu
  • View Affiliations

  • Published online on: July 7, 2016     https://doi.org/10.3892/ijo.2016.3616
  • Pages: 857-867
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Neutrophils are predominant immune cells that protect the host from microbial infection. The roles of neutrophils in tumor have long been ignored due to their short life span and terminal differentiation phenotype. In recent years, emerging evidence indicates that neutrophils have phenotypic and functional plasticity. Neutrophils eliminate malignant cells by releasing the antimicrobial and cytotoxic contents in their granules or secreting immune mediators to recruit and activate other antitumor effector cells. On the contrary, tumor derived factors can convert neutrophils into a pro-tumor phenotype. Neutrophils have been shown to facilitate tumorigenesis, promote tumor growth and metastasis, stimulate tumor angiogenesis, and mediate immunosuppression. The number of neutrophils in blood and tumor tissues of cancer patients is associated with disease progression and patient outcome. In this review, we summarize the recent progress of neutrophils in the pathogenesis of cancer with an emphasis on neutrophil polarization. Better understanding of the mechanisms that regulate the dichotomy of neutrophils will not only shed light on their roles in cancer but also provide new approaches for cancer diagnosis and treatment.
View Figures
View References

Related Articles

Journal Cover

September 2016
Volume 49 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Zhang, X., Zhang, W., Yuan, X., Fu, M., Qian, H., & Xu, W. (2016). Neutrophils in cancer development and progression: Roles, mechanisms, and implications (Review). International Journal of Oncology, 49, 857-867. https://doi.org/10.3892/ijo.2016.3616
MLA
Zhang, X., Zhang, W., Yuan, X., Fu, M., Qian, H., Xu, W."Neutrophils in cancer development and progression: Roles, mechanisms, and implications (Review)". International Journal of Oncology 49.3 (2016): 857-867.
Chicago
Zhang, X., Zhang, W., Yuan, X., Fu, M., Qian, H., Xu, W."Neutrophils in cancer development and progression: Roles, mechanisms, and implications (Review)". International Journal of Oncology 49, no. 3 (2016): 857-867. https://doi.org/10.3892/ijo.2016.3616