Neuromedin B receptor antagonism inhibits migration, invasion, and epithelial-mesenchymal transition of breast cancer cells

  • Authors:
    • Hyun-Joo Park
    • Mi-Kyoung Kim
    • Kyu-Sil Choi
    • Joo-Won Jeong
    • Soo-Kyung Bae
    • Hyung Joon Kim
    • Moon-Kyoung Bae
  • View Affiliations

  • Published online on: June 30, 2016     https://doi.org/10.3892/ijo.2016.3590
  • Pages: 934-942
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Abstract

Neuromedin B (NMB) acts as an autocrine growth factor and a pro-angiogenic factor. Its receptor, NMB receptor (NMB-R), is overexpressed in solid tumors. In the present study, we showed that an NMB-R antagonist, PD168368, suppresses migration and invasion of the human breast cancer cell line MDA-MB-231. In addition, PD168368 reduced epithelial-mesenchymal transition (EMT) of breast cancer cells by E-cadherin upregulation and vimentin downregulation. Moreover, we found that PD168368 potently inhibits in vivo metastasis of breast cancer. Taken together, these findings suggest that NMB-R antagonism may be an alternative approach to prevent breast cancer metastasis, and targeting NMB-R may provide a novel therapeutic strategy for breast cancer treatment.
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September 2016
Volume 49 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Park, H., Kim, M., Choi, K., Jeong, J., Bae, S., Kim, H.J., & Bae, M. (2016). Neuromedin B receptor antagonism inhibits migration, invasion, and epithelial-mesenchymal transition of breast cancer cells. International Journal of Oncology, 49, 934-942. https://doi.org/10.3892/ijo.2016.3590
MLA
Park, H., Kim, M., Choi, K., Jeong, J., Bae, S., Kim, H. J., Bae, M."Neuromedin B receptor antagonism inhibits migration, invasion, and epithelial-mesenchymal transition of breast cancer cells". International Journal of Oncology 49.3 (2016): 934-942.
Chicago
Park, H., Kim, M., Choi, K., Jeong, J., Bae, S., Kim, H. J., Bae, M."Neuromedin B receptor antagonism inhibits migration, invasion, and epithelial-mesenchymal transition of breast cancer cells". International Journal of Oncology 49, no. 3 (2016): 934-942. https://doi.org/10.3892/ijo.2016.3590