miR-17-92 plays an oncogenic role and conveys chemo-resistance to cisplatin in human prostate cancer cells

  • Authors:
    • Peng Zhou
    • Liang Ma
    • Jun Zhou
    • Min Jiang
    • Enyu Rao
    • Yong Zhao
    • Feng Guo
  • View Affiliations

  • Published online on: February 15, 2016     https://doi.org/10.3892/ijo.2016.3392
  • Pages: 1737-1748
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The mir-17-92 cluster consists of six mature miRNAs and is implicated in diverse human cancers by targeting mRNAs involved in distinct pathways that either promote or inhibit carcinogenesis. However, the molecular mechanism underlying the mir-17-92 cluster-mediated pro-tumorigenic or anti-tumorigenic effects has not been clearly elucidated in prostate cancer. In the present study, the role of the mir-17-92 cluster in diverse aspects of prostate cancer cells has been thoroughly investigated. Forced introduction of the mir-17-92 cluster into the androgen-independent DU145 prostate cancer cells evidently promoted cell growth due to disruption of the balance between cellular proliferation and apoptosis. Overexpression of the mir-17-92 cluster significantly improved the migration and invasion of the DU145 cells, attributed to the induction of integrin β-1. Notably, the mir-17-92 cluster conveyed chemo-resistance to cisplatin. We demonstrated that the mir-17-92 cluster suppressed the expression of inhibitor of the AKT signaling pathway and activated the AKT pathway subsequently, which played a central role in regulating cellular proliferation, apoptosis and chemo-resistance. Continuously activated ERK1/2 signaling also contributed importantly to these processes. The present study provides key evidence for crucial oncogenic role of the miR-17-92 cluster in prostate cancer cells. Further investigations are warranted to determine whether miR-17-92 cluster can be targeted for future treatment of human prostate cancer.
View Figures
View References

Related Articles

Journal Cover

April 2016
Volume 48 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Zhou, P., Ma, L., Zhou, J., Jiang, M., Rao, E., Zhao, Y., & Guo, F. (2016). miR-17-92 plays an oncogenic role and conveys chemo-resistance to cisplatin in human prostate cancer cells. International Journal of Oncology, 48, 1737-1748. https://doi.org/10.3892/ijo.2016.3392
MLA
Zhou, P., Ma, L., Zhou, J., Jiang, M., Rao, E., Zhao, Y., Guo, F."miR-17-92 plays an oncogenic role and conveys chemo-resistance to cisplatin in human prostate cancer cells". International Journal of Oncology 48.4 (2016): 1737-1748.
Chicago
Zhou, P., Ma, L., Zhou, J., Jiang, M., Rao, E., Zhao, Y., Guo, F."miR-17-92 plays an oncogenic role and conveys chemo-resistance to cisplatin in human prostate cancer cells". International Journal of Oncology 48, no. 4 (2016): 1737-1748. https://doi.org/10.3892/ijo.2016.3392