Tamoxifen enhances the differentiation-inducing and growth-inhibitory effects of all-trans retinoic acid in acute promyelocytic leukemia cells

  • Authors:
    • Koji Adachi
    • Yoshio Honma
    • Takaaki Miyake
    • Koshi Kawakami
    • Tsutomu Takahashi
    • Junji Suzumiya
  • View Affiliations

  • Published online on: January 19, 2016     https://doi.org/10.3892/ijo.2016.3348
  • Pages: 1095-1102
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Abstract

All-trans retinoic acid (ATRA) is valuable in differentiation therapy for acute promyelocytic leukemia (APL). However, ATRA has had limited success as a single agent, due to the development of resistance. We found that tamoxifen effectively enhanced the differentiation-inducing effect of ATRA. Tamoxifen alone inhibited the proliferation of myeloid leukemia cell lines while only slightly increasing morphologic differentiation. Tamoxifen effectively enhanced the growth-inhibiting actions of various differentiation-inducing agents. ATRA in the presence of tamoxifen increased NBT reduction and the expression of CD11b in HL-60 cells more effectively than ATRA alone. Tamoxifen also enhanced the differentiation induced by the other inducers tested. ATRA induced the differentiation of APL cell lines NB4 and HT93 and APL cells in primary culture, and this differentiation was also enhanced by tamoxifen. Tamoxifen is one of the most widely used drugs for the treatment of cancer and has few side effects. The combination of ATRA and tamoxifen might be considered for the treatment of APL patients in whom it can be difficult to apply arsenic trioxide or anthracyclines.
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March 2016
Volume 48 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Adachi, K., Honma, Y., Miyake, T., Kawakami, K., Takahashi, T., & Suzumiya, J. (2016). Tamoxifen enhances the differentiation-inducing and growth-inhibitory effects of all-trans retinoic acid in acute promyelocytic leukemia cells. International Journal of Oncology, 48, 1095-1102. https://doi.org/10.3892/ijo.2016.3348
MLA
Adachi, K., Honma, Y., Miyake, T., Kawakami, K., Takahashi, T., Suzumiya, J."Tamoxifen enhances the differentiation-inducing and growth-inhibitory effects of all-trans retinoic acid in acute promyelocytic leukemia cells". International Journal of Oncology 48.3 (2016): 1095-1102.
Chicago
Adachi, K., Honma, Y., Miyake, T., Kawakami, K., Takahashi, T., Suzumiya, J."Tamoxifen enhances the differentiation-inducing and growth-inhibitory effects of all-trans retinoic acid in acute promyelocytic leukemia cells". International Journal of Oncology 48, no. 3 (2016): 1095-1102. https://doi.org/10.3892/ijo.2016.3348