1,25-Dihydroxyvitamin D3 alleviates salivary adenoid cystic carcinoma progression by suppressing GPX1 expression through the NF-κB pathway

  • Authors:
    • Zhiquan Huang
    • Yeqing Liu
    • Zixian Huang
    • Haifeng Li
    • Xiangfeng Gan
    • Zhuojian Shen
  • View Affiliations

  • Published online on: January 15, 2016     https://doi.org/10.3892/ijo.2016.3341
  • Pages: 1271-1279
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Abstract

1,25-Dihydroxyvitamin D3 (1,25D3) is the active form of vitamin D with antineoplastic effects. The glutathione peroxidase-1 (GPX1) gene is associated with tumour progression. The present study aimed to explore the role of GPX1 in 1,25D3-mediated progression of salivary adenoid cystic carcinoma (SACC). Downregulating GPX1 expression inhibited SACC cell proliferation, chemoresistance, motility, and uPA secretion, but promoted apoptosis via the NF-κB pathway. Pre-processing 1,25D3 inhibited expression of NF-κB/GPX1/uPA, which subsequently suppressed cell motility and cisplatin-resistance in ACC-2 cells. In conclusion, 1,25D3 works as a modifier of NF-κB/GPX1/uPA expression, inhibiting cisplatin-resistance and cell invasive ability of SACC cells. The present study comprehensively elucidated the potential mechanism underlying the effects of vitamin D on chemoresistance and invasive potential in SACC.
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March 2016
Volume 48 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
APA
Huang, Z., Liu, Y., Huang, Z., Li, H., Gan, X., & Shen, Z. (2016). 1,25-Dihydroxyvitamin D3 alleviates salivary adenoid cystic carcinoma progression by suppressing GPX1 expression through the NF-κB pathway. International Journal of Oncology, 48, 1271-1279. https://doi.org/10.3892/ijo.2016.3341
MLA
Huang, Z., Liu, Y., Huang, Z., Li, H., Gan, X., Shen, Z."1,25-Dihydroxyvitamin D3 alleviates salivary adenoid cystic carcinoma progression by suppressing GPX1 expression through the NF-κB pathway". International Journal of Oncology 48.3 (2016): 1271-1279.
Chicago
Huang, Z., Liu, Y., Huang, Z., Li, H., Gan, X., Shen, Z."1,25-Dihydroxyvitamin D3 alleviates salivary adenoid cystic carcinoma progression by suppressing GPX1 expression through the NF-κB pathway". International Journal of Oncology 48, no. 3 (2016): 1271-1279. https://doi.org/10.3892/ijo.2016.3341