Involvement of F-box proteins in esophageal cancer (Review)

  • Authors:
    • Jian Gong
    • Zheng Huang
    • Ji-Rong Huo
  • View Affiliations

  • Published online on: January 5, 2016     https://doi.org/10.3892/ijo.2016.3325
  • Pages: 886-894
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The F-box proteins (FBPs) in esophageal tumorigenesis are pivotal as they govern a broad array of basic physiological responses including cell growth, cell death and DNA damage repair. Esophageal cancer (EC) is a common and highly aggressive cancer worldwide. Aberrant stabilization of crucial proteins participates in esophageal tumorigenesis. Recently, growing evidence has shown that FBPs play a critical role in oncogenesis, invasion, metastasis and prognosis assessment of EC. In this review we summarized published data on the roles of known FBPs, their respective substrates and the key signaling pathways, in the development of EC, aiming to uncover new ways for the rational design of targeted therapies in EC.
View Figures
View References

Related Articles

Journal Cover

March 2016
Volume 48 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Gong, J., Huang, Z., & Huo, J. (2016). Involvement of F-box proteins in esophageal cancer (Review). International Journal of Oncology, 48, 886-894. https://doi.org/10.3892/ijo.2016.3325
MLA
Gong, J., Huang, Z., Huo, J."Involvement of F-box proteins in esophageal cancer (Review)". International Journal of Oncology 48.3 (2016): 886-894.
Chicago
Gong, J., Huang, Z., Huo, J."Involvement of F-box proteins in esophageal cancer (Review)". International Journal of Oncology 48, no. 3 (2016): 886-894. https://doi.org/10.3892/ijo.2016.3325