Epithelial-mesenchymal transition and drug resistance in breast cancer (Review)

  • Authors:
    • Jing Huang
    • Hongzhong Li
    • Guosheng Ren
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  • Published online on: July 16, 2015     https://doi.org/10.3892/ijo.2015.3084
  • Pages: 840-848
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Abstract

Breast cancer is the leading cause of cancer death in women worldwide. Insensitivity of tumor cells to drug therapies is an essential reason arousing such high mortality. Epithelial-mesenchymal transition (EMT) is defined by the loss of epithelial characteristics and the acquisition of a mesenchymal phenotype. It is well known that EMT plays an important role in breast cancer progression. Recently, mounting evidence has demonstrated involvement of EMT in antagonizing chemotherapy in breast cancer. Here, we discuss the biological significance and clinical implications of these findings, with an emphasis on novel approaches that effectively target EMT to increase the efficacy of anticancer therapies.
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September 2015
Volume 47 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Huang, J., Li, H., & Ren, G. (2015). Epithelial-mesenchymal transition and drug resistance in breast cancer (Review). International Journal of Oncology, 47, 840-848. https://doi.org/10.3892/ijo.2015.3084
MLA
Huang, J., Li, H., Ren, G."Epithelial-mesenchymal transition and drug resistance in breast cancer (Review)". International Journal of Oncology 47.3 (2015): 840-848.
Chicago
Huang, J., Li, H., Ren, G."Epithelial-mesenchymal transition and drug resistance in breast cancer (Review)". International Journal of Oncology 47, no. 3 (2015): 840-848. https://doi.org/10.3892/ijo.2015.3084