Enhanced effect of photodynamic therapy in ovarian cancer using a nanoparticle drug delivery system

  • Authors:
    • Zhao Li
    • Liping Sun
    • Zaijun Lu
    • Xuantao Su
    • Qifeng Yang
    • Xun Qu
    • Li Li
    • Kun Song
    • Beihua Kong
  • View Affiliations

  • Published online on: July 10, 2015     https://doi.org/10.3892/ijo.2015.3079
  • Pages: 1070-1076
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Abstract

Nanoparticles are promising novel drug delivery carriers that allow tumor targeting and controlled drug release. In the present study, we prepared poly butyl-cyanoacrylate nanoparticles (PBCA-NP) entrapped with hypocrellin B (HB) to improve the effect of photodynamic therapy (PDT) in ovarian cancer. An ovarian cancer ascites model using Fischer 344 rats and PBCA-NP entrapped with HB (HB-PBCA-NP) were formed successfully. The pharmacodynamic characteristics and biodistribution of the HB-PBCA-NP system were evaluated by comparison with HB dimethyl sulfoxide (HB-DMSO) and testing at various time-points following intraperitoneal drug administration. HB-PBCA-NP-based PDT combined with cytoreductive surgery was then administrated to the tumor-bearing animals. Kaplan-Meier survival analysis was performed to assess the therapeutic effect of the nanoparticle system. The serum HB concentration peaked 4 h after drug administration in the nanoparticle system, and 1 h with HB-DMSO. The peak exposure time of tumor tissues was also extended (4 vs. 2 h), and PBCA-NP remained present for much longer than HB-DMSO. Although PDT combined with surgery prolonged the survival time significantly compared with surgery alone (84 days, P<0.05), there was no significant difference in the survival time of animals that received either HB-PBCA-NP- or HB-DMSO-based PDT after cytoreductive surgery (99 vs. 95 days, P=0.293). PBCA-NP exhibited potential advantages in controlled drug release and tumor targeting, which was beneficial for HB-based PDT. PDT combined with surgery prolonged the survival time, suggesting that this might be an alternative treatment option for ovarian cancer.
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September 2015
Volume 47 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Li, Z., Sun, L., Lu, Z., Su, X., Yang, Q., Qu, X. ... Kong, B. (2015). Enhanced effect of photodynamic therapy in ovarian cancer using a nanoparticle drug delivery system. International Journal of Oncology, 47, 1070-1076. https://doi.org/10.3892/ijo.2015.3079
MLA
Li, Z., Sun, L., Lu, Z., Su, X., Yang, Q., Qu, X., Li, L., Song, K., Kong, B."Enhanced effect of photodynamic therapy in ovarian cancer using a nanoparticle drug delivery system". International Journal of Oncology 47.3 (2015): 1070-1076.
Chicago
Li, Z., Sun, L., Lu, Z., Su, X., Yang, Q., Qu, X., Li, L., Song, K., Kong, B."Enhanced effect of photodynamic therapy in ovarian cancer using a nanoparticle drug delivery system". International Journal of Oncology 47, no. 3 (2015): 1070-1076. https://doi.org/10.3892/ijo.2015.3079