HIF-1α decoy oligodeoxynucleotides inhibit HIF-1α signaling and breast cancer proliferation

  • Authors:
    • Xuhong Zhu
    • Qin Li
    • Shuang Li
    • Bote Chen
    • Haidong Zou
  • View Affiliations

  • Published online on: October 21, 2014     https://doi.org/10.3892/ijo.2014.2715
  • Pages: 215-222
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Abstract

Although HIF-1α is considered an attractive target for the development of cancer therapies, like other transcriptional factors, it has been regarded as ‘undruggable’. The decoy approach is a new class of antigene strategy that can be used to modulate the function of endogenous transcriptional factors. Here, we designed a decoy oligodeoxynucleotide (ODN) and tested its effect on the function of HIF-1α. We found the HIF-1α decoy ODN could efficiently enter into cells. Furthermore, these decoy ODNs can significantly block the expression of VEGFA, a known targeted gene of HIF-1α suggesting that the HIF-1α decoy ODNs can inhibit the function of HIF-1α. More importantly, the HIF-1α decoy ODN induced apoptosis and cell cycle arrest in MDA-MB-231 breast cancer cells. In summary, HIF-1α decoy ODNs can inhibit the function of HIF-1α and induce cancer cell apoptosis. Therefore, HIF-1α decoy ODNs should be further modified to improve their biological activity in vivo.
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January 2015
Volume 46 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
APA
Zhu, X., Li, Q., Li, S., Chen, B., & Zou, H. (2015). HIF-1α decoy oligodeoxynucleotides inhibit HIF-1α signaling and breast cancer proliferation. International Journal of Oncology, 46, 215-222. https://doi.org/10.3892/ijo.2014.2715
MLA
Zhu, X., Li, Q., Li, S., Chen, B., Zou, H."HIF-1α decoy oligodeoxynucleotides inhibit HIF-1α signaling and breast cancer proliferation". International Journal of Oncology 46.1 (2015): 215-222.
Chicago
Zhu, X., Li, Q., Li, S., Chen, B., Zou, H."HIF-1α decoy oligodeoxynucleotides inhibit HIF-1α signaling and breast cancer proliferation". International Journal of Oncology 46, no. 1 (2015): 215-222. https://doi.org/10.3892/ijo.2014.2715