The alkaloid emetine sensitizes ovarian carcinoma cells to cisplatin through downregulation of bcl-xL

  • Authors:
    • Qi Sun
    • Shingo Yogosawa
    • Yosuke Iizumi
    • Toshiyuki Sakai
    • Yoshihiro Sowa
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  • Published online on: October 8, 2014     https://doi.org/10.3892/ijo.2014.2703
  • Pages: 389-394
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Abstract

Cisplatin and its platinum derivatives are first-line chemotherapeutic agents in the treatment of ovarian cancer. However, chemoresistance is the leading cause of therapeutic failure and is responsible for the poor overall survival rate. Here, we describe that emetine, a natural alkaloid used as an anti-amoebiasis drug, sensitized ovarian carcinoma cells to apoptosis induced by cisplatin. The single administration of cisplatin or emetine had a weak effect on cell death. However, co-treatment of cisplatin and emetine remarkably induced apoptosis and reduced the colony formation of ovarian carcinoma cells. Moreover, we showed that apoptosis induced by the combination of cisplatin and emetine was dependent on the activation of caspases -3, -7 and -8. As to the mechanism, downregulation of bcl-xL by emetine was shown to be responsible for enhancing the sensitivity of ovarian cancer cells to cisplatin. These findings suggest that the combination of cisplatin and emetine might be a promising treatment for ovarian cancer.
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January 2015
Volume 46 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Sun, Q., Yogosawa, S., Iizumi, Y., Sakai, T., & Sowa, Y. (2015). The alkaloid emetine sensitizes ovarian carcinoma cells to cisplatin through downregulation of bcl-xL. International Journal of Oncology, 46, 389-394. https://doi.org/10.3892/ijo.2014.2703
MLA
Sun, Q., Yogosawa, S., Iizumi, Y., Sakai, T., Sowa, Y."The alkaloid emetine sensitizes ovarian carcinoma cells to cisplatin through downregulation of bcl-xL". International Journal of Oncology 46.1 (2015): 389-394.
Chicago
Sun, Q., Yogosawa, S., Iizumi, Y., Sakai, T., Sowa, Y."The alkaloid emetine sensitizes ovarian carcinoma cells to cisplatin through downregulation of bcl-xL". International Journal of Oncology 46, no. 1 (2015): 389-394. https://doi.org/10.3892/ijo.2014.2703