Inhibition of activated Ras suppresses multiple oncogenic Hub genes in human epithelial tumors

  • Authors:
    • Lei Cao
    • Ping Wang
    • Hui Luo
    • Xi-Rui Wang
    • Xie-Feng Wang
    • Jun-Xia Zhang
    • Ying-Yi Wang
    • Lei Yao
    • Ning Liu
    • Yong-Ping You
  • View Affiliations

  • Published online on: July 3, 2014     https://doi.org/10.3892/ijo.2014.2532
  • Pages: 1609-1617
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Cancer cells may involve diverse mutations, but they often rely on continued expression of a single oncoprotein for survival, as a response to targeting this protein. Generally, Ras is overexpressed in human epithelial tumors and cancellation of activated Ras inhibits carcinoma cell proliferation and differentiation ability, and induces apoptotosis of tumor cells. However, the mechanisms of inhibition of activated Ras that suppress the malignancy activity of human epithelial tumors remain to be illuminated. We utilized text-mining of MEDLINE abstracts with natural language processing to establish the Ras biologic association network, and identified several interactions of this network with the Ras pathway. Our investigation not only examined the expression of Ras and Hub genes (PIK3CA, MDM2, CCND1, EGFR, JUN, MYC, VEGFA, ERK1 and ERK2) but also confirmed inhibition of activated Ras reduced expression of multiple oncogene in vitro studies. Our studies provide strong support for the conclusion that cancellation of activated Ras specifically regulates defective Ras pathways in human tumor cells.

Related Articles

Journal Cover

October 2014
Volume 45 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Cao, L., Wang, P., Luo, H., Wang, X., Wang, X., Zhang, J. ... You, Y. (2014). Inhibition of activated Ras suppresses multiple oncogenic Hub genes in human epithelial tumors. International Journal of Oncology, 45, 1609-1617. https://doi.org/10.3892/ijo.2014.2532
MLA
Cao, L., Wang, P., Luo, H., Wang, X., Wang, X., Zhang, J., Wang, Y., Yao, L., Liu, N., You, Y."Inhibition of activated Ras suppresses multiple oncogenic Hub genes in human epithelial tumors". International Journal of Oncology 45.4 (2014): 1609-1617.
Chicago
Cao, L., Wang, P., Luo, H., Wang, X., Wang, X., Zhang, J., Wang, Y., Yao, L., Liu, N., You, Y."Inhibition of activated Ras suppresses multiple oncogenic Hub genes in human epithelial tumors". International Journal of Oncology 45, no. 4 (2014): 1609-1617. https://doi.org/10.3892/ijo.2014.2532