The IL-6/JAK/STAT3 pathway: Potential therapeutic strategies in treating colorectal cancer (Review)

  • Authors:
    • Shu-Wei Wang
    • Yue-Ming Sun
  • View Affiliations

  • Published online on: January 15, 2014     https://doi.org/10.3892/ijo.2014.2259
  • Pages: 1032-1040
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Abstract

Among the cytokines linked to inflammation-associated cancer, interleukin (IL)-6 drives many of the cancer ‘hallmarks’ through downstream activation of the Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) signaling pathway. Additionally, dysregulation of the interleukin (IL)-6-mediated JAK/STAT3 signaling pathway is closely related to the development of diverse human solid tumors including colorectal cancer (CRC). On this basis, modulation of the IL-6/JAK/STAT3 signaling pathway is currently being widely explored to develop novel therapies for CRC. The present review details the mechanisms and roles of the IL-6/JAK/STAT3 pathway in CRC, describes current therapeutic strategies, and the search for potential therapeutic approaches to treat CRC.
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April 2014
Volume 44 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Wang, S., & Wang, S. (2014). The IL-6/JAK/STAT3 pathway: Potential therapeutic strategies in treating colorectal cancer (Review). International Journal of Oncology, 44, 1032-1040. https://doi.org/10.3892/ijo.2014.2259
MLA
Wang, S., Sun, Y."The IL-6/JAK/STAT3 pathway: Potential therapeutic strategies in treating colorectal cancer (Review)". International Journal of Oncology 44.4 (2014): 1032-1040.
Chicago
Wang, S., Sun, Y."The IL-6/JAK/STAT3 pathway: Potential therapeutic strategies in treating colorectal cancer (Review)". International Journal of Oncology 44, no. 4 (2014): 1032-1040. https://doi.org/10.3892/ijo.2014.2259