Procyanidin C1 from Cinnamomi Cortex inhibits TGF-β-induced epithelial-to-mesenchymal transition in the A549 lung cancer cell line

  • Authors:
    • Ryoei Kin
    • Shinichiro Kato
    • Naoki Kaneto
    • Hiroaki Sakurai
    • Yoshihiro Hayakawa
    • Feng Li
    • Ken Tanaka
    • Ikuo Saiki
    • Satoru Yokoyama
  • View Affiliations

  • Published online on: October 16, 2013     https://doi.org/10.3892/ijo.2013.2139
  • Pages: 1901-1906
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Abstract

Cancer metastasis is one of the most critical events in cancer patients, and the median overall survival of stage IIIb or IV patients with metastatic lung cancer in the TNM classification is only 8 or 5 months, respectively. We previously demonstrated that Juzentaihoto, a Japanese traditional medicine, can inhibit cancer metastasis through the activation of macrophages and T cells in mouse cancer metastatic models; however, the mechanism(s) through which Juzentaihoto directly affects tumor cells during the metastasis process and which herbal components from Juzentaihoto inhibit the metastatic potential have not been elucidated. In this study, we focused on the epithelial-to-mesenchymal transition (EMT), which plays an important role in the formation of cancer metastasis. We newly determined that only the Cinnamomi Cortex (CC) extract, one of 10 herbal components of Juzentaihoto, inhibits TGF-β-induced EMT. Moreover, the contents of catechin trimer in CC extracts were significantly correlated with the efficacy of inhibiting TGF-β-induced EMT. Finally, the structure of the catechin trimer from CC extract was chemically identified as procyanidin C1 and the compound showed inhibitory activity against TGF-β-induced EMT. This illustrates that procyanidin C1 is the main active compound in the CC extract responsible for EMT inhibition and that procyanidin C1 could be useful as a lead compound to develop inhibitors of cancer metastasis and other diseases related to EMT.
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December 2013
Volume 43 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Kin, R., Kato, S., Kaneto, N., Sakurai, H., Hayakawa, Y., Li, F. ... Yokoyama, S. (2013). Procyanidin C1 from Cinnamomi Cortex inhibits TGF-β-induced epithelial-to-mesenchymal transition in the A549 lung cancer cell line. International Journal of Oncology, 43, 1901-1906. https://doi.org/10.3892/ijo.2013.2139
MLA
Kin, R., Kato, S., Kaneto, N., Sakurai, H., Hayakawa, Y., Li, F., Tanaka, K., Saiki, I., Yokoyama, S."Procyanidin C1 from Cinnamomi Cortex inhibits TGF-β-induced epithelial-to-mesenchymal transition in the A549 lung cancer cell line". International Journal of Oncology 43.6 (2013): 1901-1906.
Chicago
Kin, R., Kato, S., Kaneto, N., Sakurai, H., Hayakawa, Y., Li, F., Tanaka, K., Saiki, I., Yokoyama, S."Procyanidin C1 from Cinnamomi Cortex inhibits TGF-β-induced epithelial-to-mesenchymal transition in the A549 lung cancer cell line". International Journal of Oncology 43, no. 6 (2013): 1901-1906. https://doi.org/10.3892/ijo.2013.2139