Open Access

Simvastatin reduces melanoma progression in a murine model

  • Authors:
    • Mario Zanfardino
    • Carmine Spampanato
    • Rosanna De Cicco
    • Elisabetta Buommino
    • Anna De Filippis
    • Salvatore Baiano
    • Adriano Barra
    • Franco Morelli
  • View Affiliations

  • Published online on: October 4, 2013     https://doi.org/10.3892/ijo.2013.2126
  • Pages: 1763-1770
  • Copyright: © Zanfardino et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Statins are a class of drugs that inhibit the rate-limiting step in the cholesterol biosynthetic pathway and show an anticancer effect, probably through the inhibition of cell proliferation. To date, the exact mechanism of cancer cell growth arrest induced by statins is not known. We report that simvastatin is able to induce apoptosis in melanoma cells but not in normal cells and also able to contrast the growth of tumor in an experimental melanoma murine model. We observed a delay in the tumor development in almost the 50% of the simvastatin administered animals and a strong reduction of the tumor volume with a differences of ~150% compared to the controls. Also the survival rate was significantly higher in mice that received the drug with a survival increase of ~130% compared to the controls. The tumor growth reduction in mice was supported by the results of cell migration assay, confirming that simvastatin clearly reduced cell migration. Moreover, simvastatin induced a strong downregulation of NonO gene expression, an important growth factor involved in the splicing regulation. This result could explain the decrease of melanoma cells proliferation, suggesting a possible action mechanism. The results derived from our experiments may sustain the many reports on the anticancer inhibitory property of statins and encourage new studies on this drug for a possible use in therapy, probably in combination with conventional chemotherapy.
View Figures
View References

Related Articles

Journal Cover

December 2013
Volume 43 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Zanfardino, M., Spampanato, C., De Cicco, R., Buommino, E., De Filippis, A., Baiano, S. ... Morelli, F. (2013). Simvastatin reduces melanoma progression in a murine model. International Journal of Oncology, 43, 1763-1770. https://doi.org/10.3892/ijo.2013.2126
MLA
Zanfardino, M., Spampanato, C., De Cicco, R., Buommino, E., De Filippis, A., Baiano, S., Barra, A., Morelli, F."Simvastatin reduces melanoma progression in a murine model". International Journal of Oncology 43.6 (2013): 1763-1770.
Chicago
Zanfardino, M., Spampanato, C., De Cicco, R., Buommino, E., De Filippis, A., Baiano, S., Barra, A., Morelli, F."Simvastatin reduces melanoma progression in a murine model". International Journal of Oncology 43, no. 6 (2013): 1763-1770. https://doi.org/10.3892/ijo.2013.2126