A novel resveratrol analogue, HS-1793, inhibits hypoxia-induced HIF-1α and VEGF expression, and migration in human prostate cancer cells

  • Authors:
    • Dong Hwan Kim
    • Mohammad Akbar Hossain
    • Min Young Kim
    • Jin-Ah Kim
    • Jeong-Hyun Yoon
    • Hong Suk Suh
    • Gi-Young Kim
    • Yung Hyun Choi
    • Hae Young Chung
    • Nam Deuk Kim
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  • Published online on: October 2, 2013     https://doi.org/10.3892/ijo.2013.2116
  • Pages: 1915-1924
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Abstract

In many studies, resveratrol has been shown to have a chemopreventive effect in various types of cancer cells. However, the biological activity of resveratrol is limited by its photosensitivity and metabolic instability. This study investigated the effects of a novel analogue of resveratrol, HS-1793, on the expression of HIF-1α and vascular endothelial growth factor (VEGF) in PC-3 human prostate cancer cells. Hypoxic condition induced HIF-1α protein level in PC-3 cells in a time‑dependent manner, and treatment with HS-1793 markedly decreased HIF-1α expression levels. HS-1793 also inhibited VEGF level. Mechanistically, HS-1793 inhibited HIF-1α and VEGF expression through multiple mechanisms. Firstly, HS-1793 inhibited phosphorylation of PI3K and Akt in PC-3 cells. Furthermore, HS-1793 substantially induced HIF-1α protein degradation through the proteasome pathway. Finally, HS-1793 inhibited hypoxia-induced PC-3 cell migration. These data suggest that HS-1793 may inhibit human prostate cancer progression and angiogenesis by inhibiting the expression of HIF-1α and VEGF. Moreover, HS-1793 showed more potent effects than resveratrol on the cytotoxic effects on PC-3 cells. Taken together, these results implied that HS-1793, a novel analogue of resveratrol, may be a new potent chemopreventive agent against human prostate cancer cells.
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December 2013
Volume 43 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Kim, D.H., Hossain, M.A., Kim, M.Y., Kim, J., Yoon, J., Suh, H.S. ... Kim, N.D. (2013). A novel resveratrol analogue, HS-1793, inhibits hypoxia-induced HIF-1α and VEGF expression, and migration in human prostate cancer cells. International Journal of Oncology, 43, 1915-1924. https://doi.org/10.3892/ijo.2013.2116
MLA
Kim, D. H., Hossain, M. A., Kim, M. Y., Kim, J., Yoon, J., Suh, H. S., Kim, G., Choi, Y. H., Chung, H. Y., Kim, N. D."A novel resveratrol analogue, HS-1793, inhibits hypoxia-induced HIF-1α and VEGF expression, and migration in human prostate cancer cells". International Journal of Oncology 43.6 (2013): 1915-1924.
Chicago
Kim, D. H., Hossain, M. A., Kim, M. Y., Kim, J., Yoon, J., Suh, H. S., Kim, G., Choi, Y. H., Chung, H. Y., Kim, N. D."A novel resveratrol analogue, HS-1793, inhibits hypoxia-induced HIF-1α and VEGF expression, and migration in human prostate cancer cells". International Journal of Oncology 43, no. 6 (2013): 1915-1924. https://doi.org/10.3892/ijo.2013.2116