Curcumin suppresses proliferation and induces apoptosis of human hepatocellular carcinoma cells via the wnt signaling pathway

  • Authors:
    • Marvin Xuejun Xu
    • Linlin Zhao
    • Chaoyang Deng
    • Lu Yang
    • Yang Wang
    • Tao Guo
    • Lifang Li
    • Jianping Lin
    • Lirong Zhang
  • View Affiliations

  • Published online on: September 23, 2013     https://doi.org/10.3892/ijo.2013.2107
  • Pages: 1951-1959
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Abstract

Curcumin from the rhizome of Curcuma longa (zingiberaceae) has been reported to be a chemopreventive agent that affects cell proliferation by arresting the cell cycle in G2 and modulating the wnt signaling pathway. We found that curcumin inhibits proliferation and induces apoptosis of human hepatocellular carcinoma (HCC) cells in a concentration-dependent manner. We identified that curcumin interrupts wnt signaling by decreasing β-catenin activity, which in turn suppresses the expression of β-catenin target genes (c-myc, VEGF and cyclin D1). Our results from molecular simulation of curcumin binding to Dvl2 protein and from binding free energy calculations suggest that curcumin may prevent axin recruitment to cellular membrane in order to maintain the functional β-catenin destruction complex in normal cells. This results in β-catenin being unable to accumulate in the nucleus, depriving the protein of its ability to bind with lymphoid enhancer factor/T cell-specific transcription factor (Lef/Tcf) and repressing its activation of target gene transcription. This may be one mechanism through which curcumin inhibits proliferation and induces apoptosis of HCC cells.

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December 2013
Volume 43 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
APA
Xu, M.X., Zhao, L., Deng, C., Yang, L., Wang, Y., Guo, T. ... Zhang, L. (2013). Curcumin suppresses proliferation and induces apoptosis of human hepatocellular carcinoma cells via the wnt signaling pathway. International Journal of Oncology, 43, 1951-1959. https://doi.org/10.3892/ijo.2013.2107
MLA
Xu, M. X., Zhao, L., Deng, C., Yang, L., Wang, Y., Guo, T., Li, L., Lin, J., Zhang, L."Curcumin suppresses proliferation and induces apoptosis of human hepatocellular carcinoma cells via the wnt signaling pathway". International Journal of Oncology 43.6 (2013): 1951-1959.
Chicago
Xu, M. X., Zhao, L., Deng, C., Yang, L., Wang, Y., Guo, T., Li, L., Lin, J., Zhang, L."Curcumin suppresses proliferation and induces apoptosis of human hepatocellular carcinoma cells via the wnt signaling pathway". International Journal of Oncology 43, no. 6 (2013): 1951-1959. https://doi.org/10.3892/ijo.2013.2107