Telomerase regulation: A key to inhibition? (Review)

  • Authors:
    • Diego L. Mengual Gómez
    • Hernán G. Farina
    • Daniel E. Gómez
  • View Affiliations

  • Published online on: September 16, 2013     https://doi.org/10.3892/ijo.2013.2104
  • Pages: 1351-1356
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Telomerase has been recognized as a common factor in most tumor cells, and in turn a distinctive feature with respect to non-malignant cells. This feature has made telomerase a promising target for cancer therapy. Telomerase studies revealed that it is a multi-subunit complex possessing different levels of regulation, including control of expression, phosphorylation state, assembly and transportation to sites of activity. Thus, we emphasize that targeting telomerase expression or activity is not the only way to shorten telomeres, induce cell senescence and apoptosis. Therefore, there are multiple sites capable of allowing the modulation of its enzymatic activity. In the development of strategies based on the regulation of telomerase activity the understanding of the mechanisms regulating their subunits is essential. Based on this, in this review we summarize the current state of knowledge of some regulatory mechanisms of the components of the telomerase complex, and hypothetize their potential therapeutic application against cancer.
View Figures
View References

Related Articles

Journal Cover

November 2013
Volume 43 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Gómez, D.L., Farina, H.G., & Gómez, D.E. (2013). Telomerase regulation: A key to inhibition? (Review). International Journal of Oncology, 43, 1351-1356. https://doi.org/10.3892/ijo.2013.2104
MLA
Gómez, D. L., Farina, H. G., Gómez, D. E."Telomerase regulation: A key to inhibition? (Review)". International Journal of Oncology 43.5 (2013): 1351-1356.
Chicago
Gómez, D. L., Farina, H. G., Gómez, D. E."Telomerase regulation: A key to inhibition? (Review)". International Journal of Oncology 43, no. 5 (2013): 1351-1356. https://doi.org/10.3892/ijo.2013.2104