Integrin alpha 6: A novel therapeutic target in esophageal squamous cell carcinoma

  • Authors:
    • Junhye Kwon
    • Tae-Sup Lee
    • Hae Won Lee
    • Moon Chul Kang
    • Hyeon-Joon Yoon
    • Ji-Hee Kim
    • Jong Ho Park
  • View Affiliations

  • Published online on: September 13, 2013     https://doi.org/10.3892/ijo.2013.2097
  • Pages: 1523-1530
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Abstract

Esophageal squamous cell carcinoma (ESCC), the most common subtype of esophageal cancer in East Asian countries, is a devastating disease characterized by distinctly high incidence and mortality rates. Our previous expression profile analysis showed that integrin alpha 6 (ITGA6) is highly expressed in ESCC tissues. To validate cell surface expression of ITGA6 as a novel target in ESCC, we investigated ITGA6 expression in tumor tissue samples and cell lines of ESCC and found that ITGA6 was upregulated in these cells. In vitro knockdown of ITGA6 in ESCC cells resulted in inhibition of cell proliferation, invasion and colony formation. In addition, we demonstrated that ITGA6 associates with integrin beta 4 (ITGB4), and that this heterodimer complex is upregulated in both ESCC tissues and cell lines. Moreover, our biodistribution results in an ESCC xenograft model indicated that ITGA6 is a possible target for antibody-related diagnostic and therapeutic modalities in ESCC. Thus, our findings suggest that ITGA6 plays an important role in tumorigenesis in ESCC and represents a potential therapeutic target in the treatment of ESCC.
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November 2013
Volume 43 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Kwon, J., Lee, T., Lee, H.W., Kang, M.C., Yoon, H., Kim, J., & Park, J.H. (2013). Integrin alpha 6: A novel therapeutic target in esophageal squamous cell carcinoma. International Journal of Oncology, 43, 1523-1530. https://doi.org/10.3892/ijo.2013.2097
MLA
Kwon, J., Lee, T., Lee, H. W., Kang, M. C., Yoon, H., Kim, J., Park, J. H."Integrin alpha 6: A novel therapeutic target in esophageal squamous cell carcinoma". International Journal of Oncology 43.5 (2013): 1523-1530.
Chicago
Kwon, J., Lee, T., Lee, H. W., Kang, M. C., Yoon, H., Kim, J., Park, J. H."Integrin alpha 6: A novel therapeutic target in esophageal squamous cell carcinoma". International Journal of Oncology 43, no. 5 (2013): 1523-1530. https://doi.org/10.3892/ijo.2013.2097