Mineral-enriched deep-sea water inhibits the metastatic potential of human breast cancer cell lines

  • Authors:
    • Soyoung Kim
    • So-Young Chun
    • Do-Hyung Lee
    • Kyu-Shik Lee
    • Kyung-Soo Nam
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  • Published online on: September 4, 2013     https://doi.org/10.3892/ijo.2013.2089
  • Pages: 1691-1700
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Abstract

Recently, the scientific community has begun to establish the health benefits of deep-sea water (DSW) due to its enrichment in nutrients and minerals. In this study, we investigated the effects of deep-sea water (DSW) on the metastatic potential of two human breast cancer cell lines exhibiting highly different phenotypes. MDA-MB-231 cells exhibit invasive/metastatic tumor features with rapid migration ability and high endogenous expression of TGF-β and Wnt5a. DSW treatment significantly inhibits their migratory ability in a wound-healing assay. This inhibitory effect of DSW appears to be mediated through TGF-β and Wnt5a signaling, resulting in attenuated expression of CD44. We further investigated the preventive effect of DSW on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced invasive/metastatic tumor features in non-invasive MCF-7 cells. Similar to the inhibitory effects shown in MDA-MB-231 cells, we observed that DSW treatment resulted in the inhibition of TPA-induced migration and MMP-9 activity with a concomitant decrease in mRNA levels of MMP-9, TGF-β, Wnt5a and Wnt3a. Taken together, our data show that DSW has inhibitory effects on breast cancer invasion/metastasis, suggesting that DSW has some promise in improving cancer survival by preventing tumor metastasis.
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November 2013
Volume 43 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Kim, S., Chun, S., Lee, D., Lee, K., & Nam, K. (2013). Mineral-enriched deep-sea water inhibits the metastatic potential of human breast cancer cell lines. International Journal of Oncology, 43, 1691-1700. https://doi.org/10.3892/ijo.2013.2089
MLA
Kim, S., Chun, S., Lee, D., Lee, K., Nam, K."Mineral-enriched deep-sea water inhibits the metastatic potential of human breast cancer cell lines". International Journal of Oncology 43.5 (2013): 1691-1700.
Chicago
Kim, S., Chun, S., Lee, D., Lee, K., Nam, K."Mineral-enriched deep-sea water inhibits the metastatic potential of human breast cancer cell lines". International Journal of Oncology 43, no. 5 (2013): 1691-1700. https://doi.org/10.3892/ijo.2013.2089