Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograft model

  • Authors:
    • Ming-Szu Hung
    • Zhidong Xu
    • Yu Chen
    • Emmanuel Smith
    • Jian-Hua Mao
    • David Hsieh
    • Yu-Ching Lin
    • Cheng-Ta Yang
    • David M. Jablons
    • Liang You
  • View Affiliations

  • Published online on: September 4, 2013     https://doi.org/10.3892/ijo.2013.2087
  • Pages: 1517-1522
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Abstract

Casein kinase II (CK2) inhibitors suppress cancer cell growth. In this study, we examined the inhibitory effects of a novel CK2 inhibitor, hematein, on tumor growth in a murine xenograft model. We found that in lung cancer cells, hematein inhibited cancer cell growth, Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increased apoptosis. In a murine xenograft model of lung cancer, hematein inhibited tumor growth without significant toxicity to the mice tested. Molecular docking showed that hematein binds to CK2α in durable binding sites. Collectively, our results suggest that hematein is an allosteric inhibitor of protein kinase CK2 and has antitumor activity to lung cancer.
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November 2013
Volume 43 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Hung, M., Xu, Z., Chen, Y., Smith, E., Mao, J., Hsieh, D. ... You, L. (2013). Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograft model. International Journal of Oncology, 43, 1517-1522. https://doi.org/10.3892/ijo.2013.2087
MLA
Hung, M., Xu, Z., Chen, Y., Smith, E., Mao, J., Hsieh, D., Lin, Y., Yang, C., Jablons, D. M., You, L."Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograft model". International Journal of Oncology 43.5 (2013): 1517-1522.
Chicago
Hung, M., Xu, Z., Chen, Y., Smith, E., Mao, J., Hsieh, D., Lin, Y., Yang, C., Jablons, D. M., You, L."Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograft model". International Journal of Oncology 43, no. 5 (2013): 1517-1522. https://doi.org/10.3892/ijo.2013.2087