Oncogenic function of p34SEI-1 via NEDD4‑1‑mediated PTEN ubiquitination/degradation and activation of the PI3K/AKT pathway

  • Authors:
    • Samil Jung
    • Chengping Li
    • Dongjun Jeong
    • Soonduck Lee
    • Jiyeon Ohk
    • Meeyoung Park
    • Songyi Han
    • Jingjing Duan
    • Changjin Kim
    • Young Yang
    • Keun-Il Kim
    • Jong-Seok Lim
    • Young-Sook Kang
    • Myeong-Sok Lee
  • View Affiliations

  • Published online on: August 20, 2013     https://doi.org/10.3892/ijo.2013.2064
  • Pages: 1587-1595
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Abstract

A 34-KD protein encoded by the SEI-1 gene (p34SEI‑1), is a relatively recently discovered oncoprotein that has multiple important biological functions. Our data show that p34SEI-1 enhances cancer cell survival and promotes tumorigenesis by downregulating the tumor suppressor PTEN, a negative regulator of the PI3K/AKT signaling pathway, and therefore activating the PI3K/AKT signaling pathway. In this process, p34SEI-1 positively affects NEDD4-1 gene expression both at the transcriptional and protein levels. Furthermore, the expression levels of p34SEI-1 and NEDD4-1 were found to be coordinated in tumor tissues obtained from patients with breast cancer. We also show that p34SEI-1 affects the subcellular localization of PTEN.
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November 2013
Volume 43 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
APA
Jung, S., Li, C., Jeong, D., Lee, S., Ohk, J., Park, M. ... Lee, M. (2013). Oncogenic function of p34SEI-1 via NEDD4‑1‑mediated PTEN ubiquitination/degradation and activation of the PI3K/AKT pathway. International Journal of Oncology, 43, 1587-1595. https://doi.org/10.3892/ijo.2013.2064
MLA
Jung, S., Li, C., Jeong, D., Lee, S., Ohk, J., Park, M., Han, S., Duan, J., Kim, C., Yang, Y., Kim, K., Lim, J., Kang, Y., Lee, M."Oncogenic function of p34SEI-1 via NEDD4‑1‑mediated PTEN ubiquitination/degradation and activation of the PI3K/AKT pathway". International Journal of Oncology 43.5 (2013): 1587-1595.
Chicago
Jung, S., Li, C., Jeong, D., Lee, S., Ohk, J., Park, M., Han, S., Duan, J., Kim, C., Yang, Y., Kim, K., Lim, J., Kang, Y., Lee, M."Oncogenic function of p34SEI-1 via NEDD4‑1‑mediated PTEN ubiquitination/degradation and activation of the PI3K/AKT pathway". International Journal of Oncology 43, no. 5 (2013): 1587-1595. https://doi.org/10.3892/ijo.2013.2064