Expression of Egfl7 correlates with low-grade invasive lesions in human breast cancer

  • Authors:
    • Géraldine Philippin-Lauridant
    • Marie-Christine Baranzelli
    • Chantal Samson
    • Charles Fournier
    • Sébastien Pinte
    • Virginie Mattot
    • Jacques Bonneterre
    • Fabrice Soncin
  • View Affiliations

  • Published online on: February 8, 2013     https://doi.org/10.3892/ijo.2013.1820
  • Pages: 1367-1375
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Abstract

Egfl7 (VE-statin) is specifically expressed by endothelial cells of normal tissues but its expression is deregulated in human cancers. Analysis of expression of Egfl7 protein and transcripts in 211 human breast cancer samples shows that Egfl7 is strongly expressed by breast tumor cells. Egfl7 expression is significantly higher in invasive ductal than in invasive lobular carcinoma. Expression of Egfl7 transcripts is also higher in lower SBR grade lesions and in lesions which are not associated with lymph node invasion. Within the invasive ductal carcinoma sub-population, expression of Egfl7 transcripts is correlated with the SBR score and with the ER+ status. High transcript and Egfl7 protein levels significantly correlate with the absence of axillary lymph node invasion. In lymph nodes, the levels of Egfl7 are correlated with the histological type of the primary lesions; they are higher in ductal than in lobular carcinoma. Egfl7 expression is thus associated with better prognosis factors and with the absence of lymph node invasion in human breast cancer lesions.
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April 2013
Volume 42 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Philippin-Lauridant, G., Baranzelli, M., Samson, C., Fournier, C., Pinte, S., Mattot, V. ... Soncin, F. (2013). Expression of Egfl7 correlates with low-grade invasive lesions in human breast cancer. International Journal of Oncology, 42, 1367-1375. https://doi.org/10.3892/ijo.2013.1820
MLA
Philippin-Lauridant, G., Baranzelli, M., Samson, C., Fournier, C., Pinte, S., Mattot, V., Bonneterre, J., Soncin, F."Expression of Egfl7 correlates with low-grade invasive lesions in human breast cancer". International Journal of Oncology 42.4 (2013): 1367-1375.
Chicago
Philippin-Lauridant, G., Baranzelli, M., Samson, C., Fournier, C., Pinte, S., Mattot, V., Bonneterre, J., Soncin, F."Expression of Egfl7 correlates with low-grade invasive lesions in human breast cancer". International Journal of Oncology 42, no. 4 (2013): 1367-1375. https://doi.org/10.3892/ijo.2013.1820