Ratio disruption of the ∆133p53 and TAp53 isoform equilibrium correlates with poor clinical outcome in intrahepatic cholangiocarcinoma

  • Authors:
    • Nichapavee Nutthasirikul
    • Temduang Limpaiboon
    • Chanvit Leelayuwat
    • Siriporn Patrakitkomjorn
    • Patcharee Jearanaikoon
  • View Affiliations

  • Published online on: February 8, 2013     https://doi.org/10.3892/ijo.2013.1818
  • Pages: 1181-1188
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

All p53 family members are expressed in several isoforms through alternative promoters and alternative splicing. However, the significance of these isoforms is not yet well understood in cholangiocarcinoma (CCA). In this study, we investigated the expression of p53, p63, p73 and their isoforms at the mRNA and protein levels in CCA. The overexpression of ∆133p53 was observed in the CCA cell lines and clinical specimens. Moreover, the high expression of ∆133p53/TAp53 correlated with short overall survival (p<0.001). Defective p53, including mutant and ∆Np53, was associated with poor prognosis (p<0.024). Multivariate analysis demonstrated that ∆133p53̸TAp53 and mutant p53 protein may be used as independent prognostic factors for CCA. To our knowledge, this is the first report of the use of ∆133p53̸TAp53 as a potential biomarker in CCA.
View Figures
View References

Related Articles

Journal Cover

April 2013
Volume 42 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Nutthasirikul, N., Limpaiboon, T., Leelayuwat, C., Patrakitkomjorn, S., & Jearanaikoon, P. (2013). Ratio disruption of the ∆133p53 and TAp53 isoform equilibrium correlates with poor clinical outcome in intrahepatic cholangiocarcinoma. International Journal of Oncology, 42, 1181-1188. https://doi.org/10.3892/ijo.2013.1818
MLA
Nutthasirikul, N., Limpaiboon, T., Leelayuwat, C., Patrakitkomjorn, S., Jearanaikoon, P."Ratio disruption of the ∆133p53 and TAp53 isoform equilibrium correlates with poor clinical outcome in intrahepatic cholangiocarcinoma". International Journal of Oncology 42.4 (2013): 1181-1188.
Chicago
Nutthasirikul, N., Limpaiboon, T., Leelayuwat, C., Patrakitkomjorn, S., Jearanaikoon, P."Ratio disruption of the ∆133p53 and TAp53 isoform equilibrium correlates with poor clinical outcome in intrahepatic cholangiocarcinoma". International Journal of Oncology 42, no. 4 (2013): 1181-1188. https://doi.org/10.3892/ijo.2013.1818