The effectiveness of the oncolytic activity induced by Ad5/F35 adenoviral vector is dependent on the cumulative cellular conditions of survival and autophagy

  • Authors:
    • So Y. Kim
    • Sujin Kang
    • Jae J. Song
    • Joo-Hang Kim
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  • Published online on: February 7, 2013     https://doi.org/10.3892/ijo.2013.1812
  • Pages: 1337-1348
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Abstract

To overcome the poor tumor transduction efficiency of adenovirus serotype 5 (Ad5) observed in several types of cancer, the fiber region of Ad5, apart from its tail, was replaced by adenovirus serotype 35 (Ad35). The chimeric Ad5̸F35 adenoviral vector did not exhibit any significant enhancement of transduction efficiency. CD46, a receptor for Ad35, was expressed in relatively small amounts in most of the cancer cells examined. Therefore, we investigated the pivotal factor(s) that render cancer cells susceptible to transduction. We discovered that the tumor transduction efficiency of Ad5/F35 was enhanced in the presence of rapamycin, an autophagy inducer, in some cancer cells. Analysis of survival potential and cell proliferation rates revealed that Ad5/F35 exerted a more pronounced oncolytic effect in cancer cells with higher survival potential in the presence of rapamycin.
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April 2013
Volume 42 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Kim, S.Y., Kang, S., Song, J.J., & Kim, J. (2013). The effectiveness of the oncolytic activity induced by Ad5/F35 adenoviral vector is dependent on the cumulative cellular conditions of survival and autophagy. International Journal of Oncology, 42, 1337-1348. https://doi.org/10.3892/ijo.2013.1812
MLA
Kim, S. Y., Kang, S., Song, J. J., Kim, J."The effectiveness of the oncolytic activity induced by Ad5/F35 adenoviral vector is dependent on the cumulative cellular conditions of survival and autophagy". International Journal of Oncology 42.4 (2013): 1337-1348.
Chicago
Kim, S. Y., Kang, S., Song, J. J., Kim, J."The effectiveness of the oncolytic activity induced by Ad5/F35 adenoviral vector is dependent on the cumulative cellular conditions of survival and autophagy". International Journal of Oncology 42, no. 4 (2013): 1337-1348. https://doi.org/10.3892/ijo.2013.1812