Camptothecin and cisplatin upregulate ABCG2 and MRP2 expression by activating the ATM/NF-κB pathway in lung cancer cells

  • Authors:
    • Shi Zhong Ke
    • Xiao Yan Ni
    • Yue Hua Zhang
    • Yi Nan Wang
    • Bin Wu
    • Feng Guang Gao
  • View Affiliations

  • Published online on: February 1, 2013     https://doi.org/10.3892/ijo.2013.1805
  • Pages: 1289-1296
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Abstract

Multidrug resistance (MDR) formation is an important problem in lung cancer chemotherapy. Our study showed that both camptothecin and cisplatin could not only induce ATM and NF-κB activation but also upregulate expression of the MDR-related genes ABCG2, MRP2 in NCI-H446 cells. Moreover, camptothecin and cisplatin-induced ABCG2 and MRP2 upregulation could be impaired by ATM and NF-κB inhibitors, indicating a relationship between ATM, NF-κB activation and MDR formation in lung cancer chemo­therapy. Our study indicates that ATM may serve as a potential mole­cular target for MDR formation in lung cancer chemotherapy.
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April 2013
Volume 42 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
APA
Ke, S.Z., Ni, X.Y., Zhang, Y.H., Wang, Y.N., Wu, B., & Gao, F.G. (2013). Camptothecin and cisplatin upregulate ABCG2 and MRP2 expression by activating the ATM/NF-κB pathway in lung cancer cells. International Journal of Oncology, 42, 1289-1296. https://doi.org/10.3892/ijo.2013.1805
MLA
Ke, S. Z., Ni, X. Y., Zhang, Y. H., Wang, Y. N., Wu, B., Gao, F. G."Camptothecin and cisplatin upregulate ABCG2 and MRP2 expression by activating the ATM/NF-κB pathway in lung cancer cells". International Journal of Oncology 42.4 (2013): 1289-1296.
Chicago
Ke, S. Z., Ni, X. Y., Zhang, Y. H., Wang, Y. N., Wu, B., Gao, F. G."Camptothecin and cisplatin upregulate ABCG2 and MRP2 expression by activating the ATM/NF-κB pathway in lung cancer cells". International Journal of Oncology 42, no. 4 (2013): 1289-1296. https://doi.org/10.3892/ijo.2013.1805