Open Access

Deletion polymorphism at chromosome 3q26.1 and oral squamous cell carcinoma

  • Authors:
    • Homare Kawachi
    • Keisuke Sugahara
    • Yasutaka Nakamura
    • Akira Katakura
    • Kiyoshi Minaguchi
    • Takahiko Shibahara
  • View Affiliations

  • Published online on: December 21, 2012     https://doi.org/10.3892/ijo.2012.1749
  • Pages: 384-390
  • Copyright: © Kawachi et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

Several recent studies have investigated DNA instability in malignancies including deletions and duplications of part of the chromosome using array-based comparative genomic hybridization (CGH) analysis. Using the same approach on oral squamous cell carcinoma (OSCC) tissue samples, we found a frequent deletion at chromosome 3q26.1 in OSCC patients; this polymorphism showed a gene frequency of 0.293-0.368 in healthy volunteers (n=60) and 0.129-0.195 in OSCC patients (n=54). Detailed analysis around the polymorphic region revealed the deletion breakage point. A significant association of gene frequency for the deletion polymorphism between healthy volunteers and patients implicated genetic factors related to this polymorphism in the development of OSCC. Currently, no gene is predicted to lie within the 3,606-kbp region around the polymorphism. Thus, although a single-gene model could not explain the occurrence of OSCC, we believe that examining this polymorphism could be useful in identifying risk factors for OSCC.
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February 2013
Volume 42 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
APA
Kawachi, H., Sugahara, K., Nakamura, Y., Katakura, A., Minaguchi, K., & Shibahara, T. (2013). Deletion polymorphism at chromosome 3q26.1 and oral squamous cell carcinoma. International Journal of Oncology, 42, 384-390. https://doi.org/10.3892/ijo.2012.1749
MLA
Kawachi, H., Sugahara, K., Nakamura, Y., Katakura, A., Minaguchi, K., Shibahara, T."Deletion polymorphism at chromosome 3q26.1 and oral squamous cell carcinoma". International Journal of Oncology 42.2 (2013): 384-390.
Chicago
Kawachi, H., Sugahara, K., Nakamura, Y., Katakura, A., Minaguchi, K., Shibahara, T."Deletion polymorphism at chromosome 3q26.1 and oral squamous cell carcinoma". International Journal of Oncology 42, no. 2 (2013): 384-390. https://doi.org/10.3892/ijo.2012.1749