microRNA-372 maintains oncogene characteristics by targeting TNFAIP1 and affects NFκB signaling in human gastric carcinoma cells

  • Authors:
    • Chang Zhou
    • Xiaofeng Li
    • Xiaoting Zhang
    • Xizhi Liu
    • Zhiwen Tan
    • Celi Yang
    • Jian Zhang
  • View Affiliations

  • Published online on: December 13, 2012     https://doi.org/10.3892/ijo.2012.1737
  • Pages: 635-642
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Aberrant microRNA (miRNA) expression has been investigated in gastric cancer, which is one of the most common malignancies. However, the roles of miRNAs in gastric cancer remain largely unknown. In the present study, we found that microRNA-372 (miR-372) directly targets tumor necrosis factor, α-induced protein 1 (TNFAIP1), and is involved in the regulation of the NFκB signaling pathway. Furthermore, overexpression of TNFAIP1 induced changes in AGS cells similar to those in AGS cells treated with miR-372-ASO. Collectively, these findings demonstrate an oncogenic role for miR-372 in controlling cell growth and apoptosis through downregulation of TNFAIP1. This novel molecular basis provides new insights into the etiology of gastric cancer.
View Figures
View References

Related Articles

Journal Cover

February 2013
Volume 42 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Zhou, C., Li, X., Zhang, X., Liu, X., Tan, Z., Yang, C., & Zhang, J. (2013). microRNA-372 maintains oncogene characteristics by targeting TNFAIP1 and affects NFκB signaling in human gastric carcinoma cells. International Journal of Oncology, 42, 635-642. https://doi.org/10.3892/ijo.2012.1737
MLA
Zhou, C., Li, X., Zhang, X., Liu, X., Tan, Z., Yang, C., Zhang, J."microRNA-372 maintains oncogene characteristics by targeting TNFAIP1 and affects NFκB signaling in human gastric carcinoma cells". International Journal of Oncology 42.2 (2013): 635-642.
Chicago
Zhou, C., Li, X., Zhang, X., Liu, X., Tan, Z., Yang, C., Zhang, J."microRNA-372 maintains oncogene characteristics by targeting TNFAIP1 and affects NFκB signaling in human gastric carcinoma cells". International Journal of Oncology 42, no. 2 (2013): 635-642. https://doi.org/10.3892/ijo.2012.1737