Decreased accumulation of immune regulatory cells is correlated to the antitumor effect of IFN-γ overexpression in the tumor

  • Authors:
    • Roberto Carrio
    • Marta Torroella-Kouri
    • Stephania Libreros
    • Ramón A. García-Areas
    • Vijaya Iragavarapu-Charyulu
    • Diana M. López
  • View Affiliations

  • Published online on: August 18, 2011     https://doi.org/10.3892/ijo.2011.1169
  • Pages: 1619-1627
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Abstract

During mammary tumorigenesis, there is a profound tumor-induced immunosuppression and a progressive thymic atrophy associated with tumor development. IFN-γ has been shown to be effective in enhancing antitumor responses in several tumor models, however, how IFN-γ exerts its anti-tumor effect is largely controversial. In the present study we have used a mammary tumor model to investigate whether the levels of IFN-γ have an important role in the tumor-induced immuno-suppression as well as in the pathogenesis of the thymic atrophy. We evaluated this possibility using DA-3 cells transfected to express IFN-γ (DA-3/IFN-γ), a system that provides constant, local production of IFN-γ within the tumor microenvironment. Overexpression of IFN-γ in the mammary tumor results in a marked delay of tumor growth, a reduction in regulatory T cells and myeloid-derived suppressor cells accumulation mostly due to down-regulation of chemokines implicated in the recruitment of immune regulatory cells, and a blockage in the tumor-associated thymus atrophy. Collectively, our data suggest that the replacement of the faulty levels of IFN-γ in the tumor results in a diminution of the tumor-induced immune suppression caused by the mammary tumor development.

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December 2011
Volume 39 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Carrio, R., Torroella-Kouri, M., Libreros, S., García-Areas, R.A., Iragavarapu-Charyulu, V., & López, D.M. (2011). Decreased accumulation of immune regulatory cells is correlated to the antitumor effect of IFN-γ overexpression in the tumor. International Journal of Oncology, 39, 1619-1627. https://doi.org/10.3892/ijo.2011.1169
MLA
Carrio, R., Torroella-Kouri, M., Libreros, S., García-Areas, R. A., Iragavarapu-Charyulu, V., López, D. M."Decreased accumulation of immune regulatory cells is correlated to the antitumor effect of IFN-γ overexpression in the tumor". International Journal of Oncology 39.6 (2011): 1619-1627.
Chicago
Carrio, R., Torroella-Kouri, M., Libreros, S., García-Areas, R. A., Iragavarapu-Charyulu, V., López, D. M."Decreased accumulation of immune regulatory cells is correlated to the antitumor effect of IFN-γ overexpression in the tumor". International Journal of Oncology 39, no. 6 (2011): 1619-1627. https://doi.org/10.3892/ijo.2011.1169