Current status and future potential role of exemestane in the treatment of early and advanced breast cancer (Review)

  • Authors:
    • E. Crucitta
    • M. N. Fornier
    • N. Locopo
    • N. Silvestris
    • V. Lorusso
    • M. De Lena
  • View Affiliations

  • Published online on: June 1, 2002     https://doi.org/10.3892/ijo.20.6.1283
  • Pages: 1283-1288
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Abstract

Exemestane is a new oral steroidal aromatase inactivator, active in postmenopausal women with hormonal sensitive breast carcinoma. This drug, at a dosage of 25 mg once daily, was shown to suppress in vivo aromatase activity by 97.9%, with a subsequent reduction superior to 85% of circulating oestrogen level. It exhibits definite antitumor activity at a relatively low daily dose, and is highly potent, highly selective, and well-tolerated. Moreover, for postmenopausal women with metastatic breast cancer, exemestane demonstrated a higher activity and lower toxicity profile when compared to megestrol acetate and tamoxifen in second- and first-line therapy, respectively. New data on exemestane are forthcoming both in the adjuvant and neoadjuvant setting, which could improve the management of early breast cancer in the future.

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June 2002
Volume 20 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Crucitta, E., Fornier, M.N., Locopo, N., Silvestris, N., Lorusso, V., & De Lena, M. (2002). Current status and future potential role of exemestane in the treatment of early and advanced breast cancer (Review). International Journal of Oncology, 20, 1283-1288. https://doi.org/10.3892/ijo.20.6.1283
MLA
Crucitta, E., Fornier, M. N., Locopo, N., Silvestris, N., Lorusso, V., De Lena, M."Current status and future potential role of exemestane in the treatment of early and advanced breast cancer (Review)". International Journal of Oncology 20.6 (2002): 1283-1288.
Chicago
Crucitta, E., Fornier, M. N., Locopo, N., Silvestris, N., Lorusso, V., De Lena, M."Current status and future potential role of exemestane in the treatment of early and advanced breast cancer (Review)". International Journal of Oncology 20, no. 6 (2002): 1283-1288. https://doi.org/10.3892/ijo.20.6.1283