A complex translocation event between the two homologues of chromosomes 5 leading to a del(5)(q21q33) as a sole aberration in a case clinically diagnosed as CML: Characterization of the aberration by multicolor banding

  • Authors:
    • Anita Heller
    • Heike Starke
    • Vladimir Trifonov
    • Nikolai Rubtsov
    • Ulrich Wedding
    • Ivan Loncarevic
    • Cordula Bleck
    • Uwe Claussen
    • Thomas Liehr
  • View Affiliations

  • Published online on: June 1, 2002     https://doi.org/10.3892/ijo.20.6.1179
  • Pages: 1179-1181
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Abstract

We report on a patient with a clinically diagnosed Philadelphia negative chronic myelogenous leukemia (CML) with a so far unrecorded complex translocation event between the two homologue chromosomes 5. At the GTG-band level the karyotype was normal, apart from an enlarged chromosome 5 and an extremely shortened second chromosome 5. Both derivative chromosomes 5 consisted exclusively of #5 derived material as proven by 24-color FISH. To characterize the complex aberration in more detail the multicolor banding (MCB) technique using a chromosome 5 specific probe set was applied. Using this DNA-based high resolution banding procedure, the karyotype could be described as 46,XX,del(5)(pter↷q12::q33↷qter),ins(5)(pter↷q15::q12↷q21::q21↷qter). In consequence, the aberration leads to a partial deletion of the long arm of chromosome 5: del(5)(q21q33), which would not have been identified using conventional banding techniques or 24-color FISH.

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June 2002
Volume 20 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Heller, A., Starke, H., Trifonov, V., Rubtsov, N., Wedding, U., Loncarevic, I. ... Liehr, T. (2002). A complex translocation event between the two homologues of chromosomes 5 leading to a del(5)(q21q33) as a sole aberration in a case clinically diagnosed as CML: Characterization of the aberration by multicolor banding. International Journal of Oncology, 20, 1179-1181. https://doi.org/10.3892/ijo.20.6.1179
MLA
Heller, A., Starke, H., Trifonov, V., Rubtsov, N., Wedding, U., Loncarevic, I., Bleck, C., Claussen, U., Liehr, T."A complex translocation event between the two homologues of chromosomes 5 leading to a del(5)(q21q33) as a sole aberration in a case clinically diagnosed as CML: Characterization of the aberration by multicolor banding". International Journal of Oncology 20.6 (2002): 1179-1181.
Chicago
Heller, A., Starke, H., Trifonov, V., Rubtsov, N., Wedding, U., Loncarevic, I., Bleck, C., Claussen, U., Liehr, T."A complex translocation event between the two homologues of chromosomes 5 leading to a del(5)(q21q33) as a sole aberration in a case clinically diagnosed as CML: Characterization of the aberration by multicolor banding". International Journal of Oncology 20, no. 6 (2002): 1179-1181. https://doi.org/10.3892/ijo.20.6.1179