Isolation and characterization of a novel human gene, VANGL1, as a therapeutic target for hepatocellular carcinoma

  • Authors:
    • Ryuichiro Yagyu
    • Ryuji Hamamoto
    • Yoichi Furukawa
    • Hiroshi Okabe
    • Takehira Yamamura
    • Yusuke Nakamura
  • View Affiliations

  • Published online on: June 1, 2002     https://doi.org/10.3892/ijo.20.6.1173
  • Pages: 1173-1178
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Abstract

Through analysis of genome-wide expression profiles, we have been attempting to isolate novel molecular targets for diagnosis, treatment and prevention of hepatocellular carcinoma (HCC). Among the genes that a cDNA microarray showed to be commonly transactivated in HCCs, we identified a novel human homologue of the Drosophila Van Gogh/Strabismus gene and termed it VANGL1 [Vang (Van Gogh, Drosophila)-like 1]. This gene, which encoded a transcript with an open reading frame of 1,572 bp, was expressed specifically in testis and ovary among 16 adult normal tissues examined. Transfection of antisense S-oligonucleotides, but not of sense S-oligonucleotides, into hepatoma cells suppressed expression of VANGL1 and subsequent growth of these cells was inhibited to a marked degree. The findings suggest that VANGL1 might serve as a diagnostic marker for HCC as well as a potential molecular target for development of novel therapeutic drugs.

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June 2002
Volume 20 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Yagyu, R., Hamamoto, R., Furukawa, Y., Okabe, H., Yamamura, T., & Nakamura, Y. (2002). Isolation and characterization of a novel human gene, VANGL1, as a therapeutic target for hepatocellular carcinoma. International Journal of Oncology, 20, 1173-1178. https://doi.org/10.3892/ijo.20.6.1173
MLA
Yagyu, R., Hamamoto, R., Furukawa, Y., Okabe, H., Yamamura, T., Nakamura, Y."Isolation and characterization of a novel human gene, VANGL1, as a therapeutic target for hepatocellular carcinoma". International Journal of Oncology 20.6 (2002): 1173-1178.
Chicago
Yagyu, R., Hamamoto, R., Furukawa, Y., Okabe, H., Yamamura, T., Nakamura, Y."Isolation and characterization of a novel human gene, VANGL1, as a therapeutic target for hepatocellular carcinoma". International Journal of Oncology 20, no. 6 (2002): 1173-1178. https://doi.org/10.3892/ijo.20.6.1173