Chemoprevention of breast cancer by targeting cyclooxygenase-2 and peroxisome proliferator-activated receptor-γ (Review)

  • Authors:
    • Alaa F. Badawi
    • Mostafa Z. Badr
  • View Affiliations

  • Published online on: June 1, 2002     https://doi.org/10.3892/ijo.20.6.1109
  • Pages: 1109-1122
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Abstract

Cyclooxygenase-2 (COX-2) and peroxisome proliferator-activated receptor-γ (PPARγ) have emerged as candidate molecules that hold great promise for cancer chemoprevention. COX-2 increased expression and PPARγ inactivation occur during mammary gland carcinogenesis. COX-2 and PPARγ may contribute to breast cancer induction either directly or via their effects on factors known to influence tumor development, e.g., nuclear factor-κB and vascular endothelial growth factor. Inhibition of COX-2 or activation of PPARγ prevents mammary carcinomas in experimental animals with little toxicity. Combinational treatment with COX-2 inhibitor and PPARγ agonists may produce synergistic anti-tumorigenic effects without significant toxicity and, therefore, be an effective strategy to prevent human breast cancer. Establishing a relationship between COX-2 and PPARγ in this malignancy may provide the basis for a novel chemopreventive strategy based on the modulation of both molecules simultaneously. This review evaluates experimental and epidemiological findings suggesting a possible role of COX-2 and PPARγ in the development of human breast cancer and presents evidence substantiating their coordinated action in carcinogenesis and finally develops a rationale for the simultaneous targeting of both molecules as a potentially effective strategy to prevent breast malignancy.

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June 2002
Volume 20 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Badawi, A.F., & Badawi, A.F. (2002). Chemoprevention of breast cancer by targeting cyclooxygenase-2 and peroxisome proliferator-activated receptor-γ (Review). International Journal of Oncology, 20, 1109-1122. https://doi.org/10.3892/ijo.20.6.1109
MLA
Badawi, A. F., Badr, M. Z."Chemoprevention of breast cancer by targeting cyclooxygenase-2 and peroxisome proliferator-activated receptor-γ (Review)". International Journal of Oncology 20.6 (2002): 1109-1122.
Chicago
Badawi, A. F., Badr, M. Z."Chemoprevention of breast cancer by targeting cyclooxygenase-2 and peroxisome proliferator-activated receptor-γ (Review)". International Journal of Oncology 20, no. 6 (2002): 1109-1122. https://doi.org/10.3892/ijo.20.6.1109