Electrochemotherapy can eradicate established colorectal carcinoma and leaves a systemic protective memory in mice.

  • Authors:
    • S Kuriyama
    • A Mitoro
    • H Tsujinoue
    • Y Toyokawa
    • T Nakatani
    • H Yoshiji
    • T Tsujimoto
    • H Okuda
    • S Nagao
    • H Fukui
  • View Affiliations

  • Published online on: May 1, 2000     https://doi.org/10.3892/ijo.16.5.979
  • Pages: 979-1064
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Mice bearing subcutaneously established colorectal carcinoma (CRC) were given intratumoral, intravenous or intraperitoneal injection of various doses of bleomycin (BLM), followed by the delivery of direct current, square wave electric pulses to the tumor. Approximately 50% of animals treated with electrochemotherapy with BLM had completely eradicated established CRC tumors. Importantly, it was shown that CRC-specific cytotoxic T lymphocytes were elicited in the spleens of cured animals, resulting in the protection of the rechallenge with CRC. These results indicate that electrochemotherapy with BLM is promising for the treatment of metastatic CRC as well as the original lesion.

Related Articles

Journal Cover

May 2000
Volume 16 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Kuriyama, S., Mitoro, A., Tsujinoue, H., Toyokawa, Y., Nakatani, T., Yoshiji, H. ... Fukui, H. (2000). Electrochemotherapy can eradicate established colorectal carcinoma and leaves a systemic protective memory in mice.. International Journal of Oncology, 16, 979-1064. https://doi.org/10.3892/ijo.16.5.979
MLA
Kuriyama, S., Mitoro, A., Tsujinoue, H., Toyokawa, Y., Nakatani, T., Yoshiji, H., Tsujimoto, T., Okuda, H., Nagao, S., Fukui, H."Electrochemotherapy can eradicate established colorectal carcinoma and leaves a systemic protective memory in mice.". International Journal of Oncology 16.5 (2000): 979-1064.
Chicago
Kuriyama, S., Mitoro, A., Tsujinoue, H., Toyokawa, Y., Nakatani, T., Yoshiji, H., Tsujimoto, T., Okuda, H., Nagao, S., Fukui, H."Electrochemotherapy can eradicate established colorectal carcinoma and leaves a systemic protective memory in mice.". International Journal of Oncology 16, no. 5 (2000): 979-1064. https://doi.org/10.3892/ijo.16.5.979