Pit pattern diagnosis of early colorectal carcinoma by magnifying colonoscopy: clinical and histological implications.

  • Authors:
    • S Nagata
    • S Tanaka
    • K Haruma
    • M Yoshihara
    • K Sumii
    • G Kajiyama
    • F Shimamoto
  • View Affiliations

  • Published online on: May 1, 2000     https://doi.org/10.3892/ijo.16.5.927
  • Pages: 927-961
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Abstract

The relation between subclassification of V type pit pattern and histopathologic features, particularly, in regards to the invasion depth, was examined in 75 cases of early colorectal carcinoma. After we classified two grades (VA, VN) of V type pit pattern, we subclassified VN type pit pattern into three subtypes (Grade A, B, and C) according to the degree of appearance of VN pit pattern. V type pit pattern subclassification was diagnosed with use of a magnifying colonoscope. There were 37 VA type lesions, 8 VN.Grade A type, 16 VN.Grade B type, and 14 VN.Grade C type lesions. The incidence of submucosal massive invasion (sm2, sm3) rates was 5 (14%) of the 37 VA type lesions, 3 (38%) of the 8 VN.Grade A type, 15 (94%) of the 16 VN.Grade B type and 14 (100%) of the 14 VN.Grade C type lesions, respectively. The incidence of desmoplastic reaction (++) levels in VN.Grade B and C type lesions was significantly higher than that in VA type lesions (P<0.01), and that in VN.Grade C type lesions was significantly higher than that in VN.Grade A type lesions (P<0.05). The incidence of pit disorder or destruction (+) and (++) levels in VN.Grade B and C type lesions was significantly higher than that in VA type lesions (P<0.01), and that in VN.Grade C type lesions was significantly higher than that in VN.Grade A type lesions (P<0.01). The incidence of high grade carcinoma in VN.Grade B and C type lesions was significantly higher than that in VA type lesions (P<0.01), and that in VN.Grade C type lesions was significantly higher than that in VN.Grade A type lesions (P<0.05). These findings indicate that V type pit pattern subclassification, including our new subtype, is useful for predicting the detail invasion depth of early colorectal carcinoma. These V pit pattern subtypes are based on the degrees of desmoplastic reaction, pit disorder or destruction, and histologic grade of carcinoma.

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May 2000
Volume 16 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Nagata, S., Tanaka, S., Haruma, K., Yoshihara, M., Sumii, K., Kajiyama, G., & Shimamoto, F. (2000). Pit pattern diagnosis of early colorectal carcinoma by magnifying colonoscopy: clinical and histological implications.. International Journal of Oncology, 16, 927-961. https://doi.org/10.3892/ijo.16.5.927
MLA
Nagata, S., Tanaka, S., Haruma, K., Yoshihara, M., Sumii, K., Kajiyama, G., Shimamoto, F."Pit pattern diagnosis of early colorectal carcinoma by magnifying colonoscopy: clinical and histological implications.". International Journal of Oncology 16.5 (2000): 927-961.
Chicago
Nagata, S., Tanaka, S., Haruma, K., Yoshihara, M., Sumii, K., Kajiyama, G., Shimamoto, F."Pit pattern diagnosis of early colorectal carcinoma by magnifying colonoscopy: clinical and histological implications.". International Journal of Oncology 16, no. 5 (2000): 927-961. https://doi.org/10.3892/ijo.16.5.927