Induction of apoptosis by hexamethylene bisacetamide is p53-dependent associated with telomerase activity but not with terminal differentiation.

  • Authors:
    • Z Zhang
    • E C Liong
    • T Y Lau
    • K M Leung
    • P C Fung
    • G L Tipoe
  • View Affiliations

  • Published online on: May 1, 2000     https://doi.org/10.3892/ijo.16.5.887
  • Pages: 887-979
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Abstract

The present study investigated the relationships amongst apoptosis, terminal differentiation and telomerase activity in human colon carcinoma cells. We found that hexamethylene bisacetamide (HMBA) induced apoptosis in human colon carcinoma LoVo cells harbouring wild-type p53 but not in SW1116 cells harbouring mutant p53. HMBA reduced telomerase activity in both colon carcinoma cells but it did not induce differentiation in the colon carcinoma cells. Taken together, our results suggest that HMBA can induce apoptosis via a p53-dependent pathway, but apoptosis and terminal differentiation may be separately regulated in LoVo cells. Inhibition of telomerase activity may activate apoptosis through a p53-dependent mechanism.

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May 2000
Volume 16 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Zhang, Z., Liong, E., Lau, T., Leung, K., Fung, P., & Tipoe, G. (2000). Induction of apoptosis by hexamethylene bisacetamide is p53-dependent associated with telomerase activity but not with terminal differentiation.. International Journal of Oncology, 16, 887-979. https://doi.org/10.3892/ijo.16.5.887
MLA
Zhang, Z., Liong, E., Lau, T., Leung, K., Fung, P., Tipoe, G."Induction of apoptosis by hexamethylene bisacetamide is p53-dependent associated with telomerase activity but not with terminal differentiation.". International Journal of Oncology 16.5 (2000): 887-979.
Chicago
Zhang, Z., Liong, E., Lau, T., Leung, K., Fung, P., Tipoe, G."Induction of apoptosis by hexamethylene bisacetamide is p53-dependent associated with telomerase activity but not with terminal differentiation.". International Journal of Oncology 16, no. 5 (2000): 887-979. https://doi.org/10.3892/ijo.16.5.887