Transgenic animal models of human papillomavirus-dependent disease (Review).

  • Authors:
    • R L Eckert
    • J F Crish
    • S Balasubramanian
    • E A Rorke
  • View Affiliations

  • Published online on: May 1, 2000     https://doi.org/10.3892/ijo.16.5.853
  • Pages: 853-923
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Abstract

Human papillomaviruses (HPVs) are DNA tumor viruses that induce hyperproliferative lesions in cutaneous and mucosal epithelia. A wide variety of studies implicate the viral E6 and E7 oncoproteins as cell immortalizing agents, and show that these proteins work, respectively, by interfering with the function of the p53 and pRb tumor suppressor genes. Most of these studies have been performed using cell culture models. However, recently, a variety of in vivo mouse model systems have been developed for the study of HPV-dependent disease. These models use tissue-specific promoters to deliver HPV oncoprotein expression to specific body sites. Using this strategy, mouse models have been designed for the study of cancer progression in epithelia, and additional models have been designed to use E6 and E7, respectively, to probe the role of p53 and pRb on tissue differentiation and function. In the present report, we summarize the literature describing these systems, and highlight some of the important findings derived from these studies.

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May 2000
Volume 16 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Eckert, R., Crish, J., Balasubramanian, S., & Rorke, E. (2000). Transgenic animal models of human papillomavirus-dependent disease (Review).. International Journal of Oncology, 16, 853-923. https://doi.org/10.3892/ijo.16.5.853
MLA
Eckert, R., Crish, J., Balasubramanian, S., Rorke, E."Transgenic animal models of human papillomavirus-dependent disease (Review).". International Journal of Oncology 16.5 (2000): 853-923.
Chicago
Eckert, R., Crish, J., Balasubramanian, S., Rorke, E."Transgenic animal models of human papillomavirus-dependent disease (Review).". International Journal of Oncology 16, no. 5 (2000): 853-923. https://doi.org/10.3892/ijo.16.5.853